FASTAptamer: A Bioinformatic Toolkit for High-throughput Sequence Analysis of Combinatorial Selections

FASTAptamer: A Bioinformatic Toolkit for High-throughput Sequence Analysis of Combinatorial Selections

High-throughput sequence (HTS) analysis of combinatorial selection populations accelerates lead discovery and optimization and offers dynamic insight into selection processes. An underlying principle is that selection enriches high-fitness sequences as a fraction of the population, whereas low-fitne...

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Bibliographic Details
Main Authors: Khalid K Alam, Jonathan L Chang, Donald H Burke
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aptamer
bioinformatics
high-throughput sequence
next-generation sequencing
phage display
ribozyme
sequencing
SELEX
software
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300166

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