Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains
Abstract Objective Evaluate bovine viral diarrhea virus (BVDV) antigenicity by using virus neutralization titers (VNT) analyzed using the principal component analysis (PCA) from antisera generated against US-based vaccine strains against both US-origin field isolates and non-US-origin field isolates...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-023-06410-2 |
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| author | Ana Cristina S. Mosena Hao Ma Eduardo Casas Rohana P. Dassanayake Cláudio W. Canal John D. Neill Shollie M. Falkenberg |
| author_facet | Ana Cristina S. Mosena Hao Ma Eduardo Casas Rohana P. Dassanayake Cláudio W. Canal John D. Neill Shollie M. Falkenberg |
| author_sort | Ana Cristina S. Mosena |
| collection | DOAJ |
| description | Abstract Objective Evaluate bovine viral diarrhea virus (BVDV) antigenicity by using virus neutralization titers (VNT) analyzed using the principal component analysis (PCA) from antisera generated against US-based vaccine strains against both US-origin field isolates and non-US-origin field isolates. Results Data from both independent analyses demonstrated that several US-origin and non-US-origin BVDV field isolates appear to be antigenically divergent from the US-based vaccine strains. Results from the combined analysis provided greater insight into the antigenic diversity observed among BVDV isolates. Data from this study further support genetic assignment into BVDV subgenotypes, as well as strains within subgenotypes is not representative of antigenic relatedness. PCA highlights isolates that are antigenically divergent from members of the same species and subgenotype and conversely isolates that belong to different subgenotypes have similar antigenic characteristics when using antisera from US-based vaccine isolates. |
| first_indexed | 2024-03-13T01:58:16Z |
| format | Article |
| id | doaj.art-58600d12973b4214920b114f7c451036 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-03-13T01:58:16Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-58600d12973b4214920b114f7c4510362023-07-02T11:06:09ZengBMCBMC Research Notes1756-05002023-06-011611610.1186/s13104-023-06410-2Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strainsAna Cristina S. Mosena0Hao Ma1Eduardo Casas2Rohana P. Dassanayake3Cláudio W. Canal4John D. Neill5Shollie M. Falkenberg6Ruminant Disease and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research ServiceRuminant Disease and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research ServiceRuminant Disease and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research ServiceRuminant Disease and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research ServiceLaboratório de Virologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS)Ruminant Disease and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research ServiceCollege of Veterinary Medicine, Department of Pathobiology, Auburn UniversityAbstract Objective Evaluate bovine viral diarrhea virus (BVDV) antigenicity by using virus neutralization titers (VNT) analyzed using the principal component analysis (PCA) from antisera generated against US-based vaccine strains against both US-origin field isolates and non-US-origin field isolates. Results Data from both independent analyses demonstrated that several US-origin and non-US-origin BVDV field isolates appear to be antigenically divergent from the US-based vaccine strains. Results from the combined analysis provided greater insight into the antigenic diversity observed among BVDV isolates. Data from this study further support genetic assignment into BVDV subgenotypes, as well as strains within subgenotypes is not representative of antigenic relatedness. PCA highlights isolates that are antigenically divergent from members of the same species and subgenotype and conversely isolates that belong to different subgenotypes have similar antigenic characteristics when using antisera from US-based vaccine isolates.https://doi.org/10.1186/s13104-023-06410-2PCAAntigenicitypestivirusBVDVVirus neutralization |
| spellingShingle | Ana Cristina S. Mosena Hao Ma Eduardo Casas Rohana P. Dassanayake Cláudio W. Canal John D. Neill Shollie M. Falkenberg Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains BMC Research Notes PCA Antigenicity pestivirus BVDV Virus neutralization |
| title | Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains |
| title_full | Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains |
| title_fullStr | Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains |
| title_full_unstemmed | Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains |
| title_short | Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains |
| title_sort | multivariate analysis reveals that bvdv field isolates do not show a close vn based antigenic relationship to us vaccine strains |
| topic | PCA Antigenicity pestivirus BVDV Virus neutralization |
| url | https://doi.org/10.1186/s13104-023-06410-2 |
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