<i>Fissistigma oldhamii</i> (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects
The species <i>Fissistigma oldhamii</i> (Hemsl.) Merr. (Annonaceae) has long been used as a traditional herbal medicine in China to treat diverse human diseases. Decoctions from the roots of the plant (Guā Fù Mù) are used to treat body pain and inflammatory pathologies, such as rheumatic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/24/4094 |
| _version_ | 1797372358479052800 |
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| author | Christian Bailly |
| author_facet | Christian Bailly |
| author_sort | Christian Bailly |
| collection | DOAJ |
| description | The species <i>Fissistigma oldhamii</i> (Hemsl.) Merr. (Annonaceae) has long been used as a traditional herbal medicine in China to treat diverse human diseases. Decoctions from the roots of the plant (Guā Fù Mù) are used to treat body pain and inflammatory pathologies, such as rheumatic syndromes, sciatica, and osteoarthritis. The phytochemical content of the plant and the associated pharmacological activities have been analyzed. Seventy natural products were identified in the different parts of the plants, namely, the roots, stems, leaves, fruits, and seeds. The compounds comprise many tri- and tetracyclic alkaloids (aporphine-type), anthraquinones, terpenoids, flavonoids, and others. The pharmacological properties of these molecules were analyzed to point out the anti-inflammatory, antioxidant, anticancer, and/or antimicrobial effects, together with the underlying modulated pathways and molecular targets in some cases. The panel of phytoconstituents present in <i>F. oldhamii</i> extracts is large, with the majority of bioactive products identified in the roots and stems. Multiple molecules can contribute to the anti-inflammatory properties of the extracts. Network pharmacology analyses of the phytoconstituents are needed to better delineate the effective components and their targets. |
| first_indexed | 2024-03-08T18:34:43Z |
| format | Article |
| id | doaj.art-5862ba4062e14633b0872acde98e3d41 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-08T18:34:43Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-5862ba4062e14633b0872acde98e3d412023-12-29T15:47:20ZengMDPI AGPlants2223-77472023-12-011224409410.3390/plants12244094<i>Fissistigma oldhamii</i> (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological AspectsChristian Bailly0CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, OncoLille Institut, University of Lille, 59000 Lille, FranceThe species <i>Fissistigma oldhamii</i> (Hemsl.) Merr. (Annonaceae) has long been used as a traditional herbal medicine in China to treat diverse human diseases. Decoctions from the roots of the plant (Guā Fù Mù) are used to treat body pain and inflammatory pathologies, such as rheumatic syndromes, sciatica, and osteoarthritis. The phytochemical content of the plant and the associated pharmacological activities have been analyzed. Seventy natural products were identified in the different parts of the plants, namely, the roots, stems, leaves, fruits, and seeds. The compounds comprise many tri- and tetracyclic alkaloids (aporphine-type), anthraquinones, terpenoids, flavonoids, and others. The pharmacological properties of these molecules were analyzed to point out the anti-inflammatory, antioxidant, anticancer, and/or antimicrobial effects, together with the underlying modulated pathways and molecular targets in some cases. The panel of phytoconstituents present in <i>F. oldhamii</i> extracts is large, with the majority of bioactive products identified in the roots and stems. Multiple molecules can contribute to the anti-inflammatory properties of the extracts. Network pharmacology analyses of the phytoconstituents are needed to better delineate the effective components and their targets.https://www.mdpi.com/2223-7747/12/24/4094anticanceranti-inflammatory<i>Fissistigma oldhamii</i>phytochemicalstraditional medicine |
| spellingShingle | Christian Bailly <i>Fissistigma oldhamii</i> (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Plants anticancer anti-inflammatory <i>Fissistigma oldhamii</i> phytochemicals traditional medicine |
| title | <i>Fissistigma oldhamii</i> (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects |
| title_full | <i>Fissistigma oldhamii</i> (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects |
| title_fullStr | <i>Fissistigma oldhamii</i> (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects |
| title_full_unstemmed | <i>Fissistigma oldhamii</i> (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects |
| title_short | <i>Fissistigma oldhamii</i> (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects |
| title_sort | i fissistigma oldhamii i hemsl merr ethnomedicinal phytochemistry and pharmacological aspects |
| topic | anticancer anti-inflammatory <i>Fissistigma oldhamii</i> phytochemicals traditional medicine |
| url | https://www.mdpi.com/2223-7747/12/24/4094 |
| work_keys_str_mv | AT christianbailly ifissistigmaoldhamiiihemslmerrethnomedicinalphytochemistryandpharmacologicalaspects |