Recent advancements in nanoelectrospray ionization interface and coupled devices
As a major sample introduction method, electrospray ionization has been widely used as the frontend interface for mass spectrometry due to its unique advantages, including high ionization efficiency, no sample breakage, ionization capability for polar and macromolecular samples, and ease of modifica...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Journal of Chromatography Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772391722000342 |
| _version_ | 1811178709390983168 |
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| author | Shiyi Chen Juxing Zeng Zhendian Zhang Bolin Xu Bo Zhang |
| author_facet | Shiyi Chen Juxing Zeng Zhendian Zhang Bolin Xu Bo Zhang |
| author_sort | Shiyi Chen |
| collection | DOAJ |
| description | As a major sample introduction method, electrospray ionization has been widely used as the frontend interface for mass spectrometry due to its unique advantages, including high ionization efficiency, no sample breakage, ionization capability for polar and macromolecular samples, and ease of modification. Lowing the flow rate to the nanoelectrospray regime (<1000 nL/min) not only reduces sample consumption and increases sensitivity, but also tolerates high concentrations of matrix salts, which is beneficial to sensitively analyzing trace biological samples. While the nanoelectrospray performance is highly related to emitter structures, different designs and architectures of the nanoelectrospray interface also have a great impact on the operational approaches and analytical targets. In this review, we summarized and discussed recent developments in nanoelectrospray modules that have a significant impact on the performance and functionality of the nanoelectrospray ionization interface, including emitter, sample injection, and electrical contact. The mechanisms and applications of these newly-developed nanoelectrospray interfaces will also be discussed. |
| first_indexed | 2024-04-11T06:22:53Z |
| format | Article |
| id | doaj.art-58634dbd30f147648e322c5f49bb2a4b |
| institution | Directory Open Access Journal |
| issn | 2772-3917 |
| language | English |
| last_indexed | 2024-04-11T06:22:53Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Chromatography Open |
| spelling | doaj.art-58634dbd30f147648e322c5f49bb2a4b2022-12-22T04:40:29ZengElsevierJournal of Chromatography Open2772-39172022-11-012100064Recent advancements in nanoelectrospray ionization interface and coupled devicesShiyi Chen0Juxing Zeng1Zhendian Zhang2Bolin Xu3Bo Zhang4Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, ChinaDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, ChinaDepartment of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, ChinaAnhui Chromatography Instrument Co Ltd., Hefei 230031, ChinaCorresponding author at: Department of Chemistry, Xiamen University, 422 Siming South Road, Xiamen, Fujian Province 361005, China.; Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, ChinaAs a major sample introduction method, electrospray ionization has been widely used as the frontend interface for mass spectrometry due to its unique advantages, including high ionization efficiency, no sample breakage, ionization capability for polar and macromolecular samples, and ease of modification. Lowing the flow rate to the nanoelectrospray regime (<1000 nL/min) not only reduces sample consumption and increases sensitivity, but also tolerates high concentrations of matrix salts, which is beneficial to sensitively analyzing trace biological samples. While the nanoelectrospray performance is highly related to emitter structures, different designs and architectures of the nanoelectrospray interface also have a great impact on the operational approaches and analytical targets. In this review, we summarized and discussed recent developments in nanoelectrospray modules that have a significant impact on the performance and functionality of the nanoelectrospray ionization interface, including emitter, sample injection, and electrical contact. The mechanisms and applications of these newly-developed nanoelectrospray interfaces will also be discussed.http://www.sciencedirect.com/science/article/pii/S2772391722000342Electrospray ionizationNanoelectrosprayInterface technologyEmitterMass spectrometry |
| spellingShingle | Shiyi Chen Juxing Zeng Zhendian Zhang Bolin Xu Bo Zhang Recent advancements in nanoelectrospray ionization interface and coupled devices Journal of Chromatography Open Electrospray ionization Nanoelectrospray Interface technology Emitter Mass spectrometry |
| title | Recent advancements in nanoelectrospray ionization interface and coupled devices |
| title_full | Recent advancements in nanoelectrospray ionization interface and coupled devices |
| title_fullStr | Recent advancements in nanoelectrospray ionization interface and coupled devices |
| title_full_unstemmed | Recent advancements in nanoelectrospray ionization interface and coupled devices |
| title_short | Recent advancements in nanoelectrospray ionization interface and coupled devices |
| title_sort | recent advancements in nanoelectrospray ionization interface and coupled devices |
| topic | Electrospray ionization Nanoelectrospray Interface technology Emitter Mass spectrometry |
| url | http://www.sciencedirect.com/science/article/pii/S2772391722000342 |
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