Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine
Abstract Increased body fluids during pregnancy complicates the application of estimated glomerular filtration rate (eGFR) formulas that are based on body surface area. Furthermore, gestational renal dysfunction cannot be identified if the serum creatinine (SCr) concentration is within the non-pregn...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-57737-0 |
| _version_ | 1797233521939447808 |
|---|---|
| author | Kwangjin Ahn Taesic Lee Jieun Kang Seong Jin Choi Sangwon Hwang Dong Min Seo Jooyoung Cho Young Uh |
| author_facet | Kwangjin Ahn Taesic Lee Jieun Kang Seong Jin Choi Sangwon Hwang Dong Min Seo Jooyoung Cho Young Uh |
| author_sort | Kwangjin Ahn |
| collection | DOAJ |
| description | Abstract Increased body fluids during pregnancy complicates the application of estimated glomerular filtration rate (eGFR) formulas that are based on body surface area. Furthermore, gestational renal dysfunction cannot be identified if the serum creatinine (SCr) concentration is within the non-pregnant reference interval (RI) despite inadequate pregnancy-related renal hyperfiltration. 1484 SCr measurements from 957 healthy pregnant women were collected. The average SCr value of gestational week (GW) 0–3 was the representative SCr value of non-pregnant status. While the distribution of SCr measurements varied across GWs, it was transformed into a normal distribution using the bootstrap resampling method. A polynomial linear regression method was applied to achieve a continuous and smooth transformation of values. The normally distributed SCr values of each GW were compared to the non-pregnant status, leading to the calculation of SCr hyperfiltration. The final equation, (2 − SCr (μmol/L) $$/$$ / 55.25) $$\times$$ × 103.1 $$\times$$ × 55.25/(56.7 − 0.223 $$\times$$ × GW − 0.113 $$\times$$ × GW2 $$+$$ + 0.00545 $$\times$$ × GW3 − 0.0000653 $$\times$$ × GW4), and reference intervals for both SCr and eGFR for each GW were obtained. These RIs and novel equations can be effectively used to monitor renal dysfunction in pregnant women. |
| first_indexed | 2024-04-24T16:17:30Z |
| format | Article |
| id | doaj.art-5866cd48de6b48b88bad6ab8df12367a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T16:17:30Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5866cd48de6b48b88bad6ab8df12367a2024-03-31T11:21:10ZengNature PortfolioScientific Reports2045-23222024-03-0114111110.1038/s41598-024-57737-0Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinineKwangjin Ahn0Taesic Lee1Jieun Kang2Seong Jin Choi3Sangwon Hwang4Dong Min Seo5Jooyoung Cho6Young Uh7Department of Laboratory Medicine, Yonsei University Wonju College of MedicineDepartment of Family Medicine, Yonsei University Wonju College of MedicineDepartment of Obstetrics and Gynecology, Yonsei University Wonju College of MedicineDepartment of Obstetrics and Gynecology, Yonsei University Wonju College of MedicineDepartment of Precision Medicine, Yonsei University Wonju College of MedicineDepartment of Medical Information, Yonsei University Wonju College of MedicineDepartment of Laboratory Medicine, Yonsei University Wonju College of MedicineDepartment of Laboratory Medicine, Yonsei University Wonju College of MedicineAbstract Increased body fluids during pregnancy complicates the application of estimated glomerular filtration rate (eGFR) formulas that are based on body surface area. Furthermore, gestational renal dysfunction cannot be identified if the serum creatinine (SCr) concentration is within the non-pregnant reference interval (RI) despite inadequate pregnancy-related renal hyperfiltration. 1484 SCr measurements from 957 healthy pregnant women were collected. The average SCr value of gestational week (GW) 0–3 was the representative SCr value of non-pregnant status. While the distribution of SCr measurements varied across GWs, it was transformed into a normal distribution using the bootstrap resampling method. A polynomial linear regression method was applied to achieve a continuous and smooth transformation of values. The normally distributed SCr values of each GW were compared to the non-pregnant status, leading to the calculation of SCr hyperfiltration. The final equation, (2 − SCr (μmol/L) $$/$$ / 55.25) $$\times$$ × 103.1 $$\times$$ × 55.25/(56.7 − 0.223 $$\times$$ × GW − 0.113 $$\times$$ × GW2 $$+$$ + 0.00545 $$\times$$ × GW3 − 0.0000653 $$\times$$ × GW4), and reference intervals for both SCr and eGFR for each GW were obtained. These RIs and novel equations can be effectively used to monitor renal dysfunction in pregnant women.https://doi.org/10.1038/s41598-024-57737-0 |
| spellingShingle | Kwangjin Ahn Taesic Lee Jieun Kang Seong Jin Choi Sangwon Hwang Dong Min Seo Jooyoung Cho Young Uh Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine Scientific Reports |
| title | Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine |
| title_full | Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine |
| title_fullStr | Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine |
| title_full_unstemmed | Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine |
| title_short | Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine |
| title_sort | development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine |
| url | https://doi.org/10.1038/s41598-024-57737-0 |
| work_keys_str_mv | AT kwangjinahn developmentofaformulaforestimatedglomerularfiltrationrateinpregnantwomenfromphysiologicalhyperfiltrationofserumcreatinine AT taesiclee developmentofaformulaforestimatedglomerularfiltrationrateinpregnantwomenfromphysiologicalhyperfiltrationofserumcreatinine AT jieunkang developmentofaformulaforestimatedglomerularfiltrationrateinpregnantwomenfromphysiologicalhyperfiltrationofserumcreatinine AT seongjinchoi developmentofaformulaforestimatedglomerularfiltrationrateinpregnantwomenfromphysiologicalhyperfiltrationofserumcreatinine AT sangwonhwang developmentofaformulaforestimatedglomerularfiltrationrateinpregnantwomenfromphysiologicalhyperfiltrationofserumcreatinine AT dongminseo developmentofaformulaforestimatedglomerularfiltrationrateinpregnantwomenfromphysiologicalhyperfiltrationofserumcreatinine AT jooyoungcho developmentofaformulaforestimatedglomerularfiltrationrateinpregnantwomenfromphysiologicalhyperfiltrationofserumcreatinine AT younguh developmentofaformulaforestimatedglomerularfiltrationrateinpregnantwomenfromphysiologicalhyperfiltrationofserumcreatinine |