Transcranial magnetic stimulation set-up for small animals
Transcranial magnetic stimulation (TMS) is widely applied on humans for research and clinical purposes. TMS studies on small animals, e.g., rodents, can provide valuable knowledge of the underlying neurophysiological mechanisms. Administering TMS on small animals is, however, prone to technical diff...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.935268/full |
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| author | Jaakko O. Nieminen Jaakko O. Nieminen Jaakko O. Nieminen Alexey S. Pospelov Alexey S. Pospelov Alexey S. Pospelov Lari M. Koponen Pauliina Yrjölä Pauliina Yrjölä Pauliina Yrjölä Anastasia Shulga Anastasia Shulga Stanislav Khirug Claudio Rivera Claudio Rivera |
| author_facet | Jaakko O. Nieminen Jaakko O. Nieminen Jaakko O. Nieminen Alexey S. Pospelov Alexey S. Pospelov Alexey S. Pospelov Lari M. Koponen Pauliina Yrjölä Pauliina Yrjölä Pauliina Yrjölä Anastasia Shulga Anastasia Shulga Stanislav Khirug Claudio Rivera Claudio Rivera |
| author_sort | Jaakko O. Nieminen |
| collection | DOAJ |
| description | Transcranial magnetic stimulation (TMS) is widely applied on humans for research and clinical purposes. TMS studies on small animals, e.g., rodents, can provide valuable knowledge of the underlying neurophysiological mechanisms. Administering TMS on small animals is, however, prone to technical difficulties, mainly due to their small head size. In this study, we aimed to develop an energy-efficient coil and a compatible experimental set-up for administering TMS on rodents. We applied a convex optimization process to develop a minimum-energy coil for TMS on rats. As the coil windings of the optimized coil extend to a wide region, we designed and manufactured a holder on which the rat lies upside down, with its head supported by the coil. We used the set-up to record TMS–electromyography, with electromyography recorded from limb muscles with intramuscular electrodes. The upside-down placement of the rat allowed the operator to easily navigate the TMS without the coil blocking their field of view. With this paradigm, we obtained consistent motor evoked potentials from all tested animals. |
| first_indexed | 2024-04-12T11:08:54Z |
| format | Article |
| id | doaj.art-58678505ae4442e984ac581d8418029e |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T11:08:54Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-58678505ae4442e984ac581d8418029e2022-12-22T03:35:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-11-011610.3389/fnins.2022.935268935268Transcranial magnetic stimulation set-up for small animalsJaakko O. Nieminen0Jaakko O. Nieminen1Jaakko O. Nieminen2Alexey S. Pospelov3Alexey S. Pospelov4Alexey S. Pospelov5Lari M. Koponen6Pauliina Yrjölä7Pauliina Yrjölä8Pauliina Yrjölä9Anastasia Shulga10Anastasia Shulga11Stanislav Khirug12Claudio Rivera13Claudio Rivera14Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, FinlandBioMag Laboratory, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandBiomedical Imaging Unit, A.I. Virtanen Institute, University of Eastern Finland, Kuopio, FinlandFaculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences, University of Helsinki, Helsinki, FinlandDepartment of Clinical Neurophysiology, BABA Center, Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, FinlandNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, FinlandDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, FinlandBioMag Laboratory, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandDepartment of Clinical Neurophysiology, BABA Center, Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, FinlandNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, FinlandBioMag Laboratory, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandDepartment of Physical and Rehabilitation Medicine, Helsinki University Hospital, Helsinki, FinlandNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, FinlandNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, FinlandINMED (INSERM U1249), Aix-Marseille Université, Marseille, FranceTranscranial magnetic stimulation (TMS) is widely applied on humans for research and clinical purposes. TMS studies on small animals, e.g., rodents, can provide valuable knowledge of the underlying neurophysiological mechanisms. Administering TMS on small animals is, however, prone to technical difficulties, mainly due to their small head size. In this study, we aimed to develop an energy-efficient coil and a compatible experimental set-up for administering TMS on rodents. We applied a convex optimization process to develop a minimum-energy coil for TMS on rats. As the coil windings of the optimized coil extend to a wide region, we designed and manufactured a holder on which the rat lies upside down, with its head supported by the coil. We used the set-up to record TMS–electromyography, with electromyography recorded from limb muscles with intramuscular electrodes. The upside-down placement of the rat allowed the operator to easily navigate the TMS without the coil blocking their field of view. With this paradigm, we obtained consistent motor evoked potentials from all tested animals.https://www.frontiersin.org/articles/10.3389/fnins.2022.935268/fulltranscranial magnetic stimulationTMScoilholderelectromyographyrat |
| spellingShingle | Jaakko O. Nieminen Jaakko O. Nieminen Jaakko O. Nieminen Alexey S. Pospelov Alexey S. Pospelov Alexey S. Pospelov Lari M. Koponen Pauliina Yrjölä Pauliina Yrjölä Pauliina Yrjölä Anastasia Shulga Anastasia Shulga Stanislav Khirug Claudio Rivera Claudio Rivera Transcranial magnetic stimulation set-up for small animals Frontiers in Neuroscience transcranial magnetic stimulation TMS coil holder electromyography rat |
| title | Transcranial magnetic stimulation set-up for small animals |
| title_full | Transcranial magnetic stimulation set-up for small animals |
| title_fullStr | Transcranial magnetic stimulation set-up for small animals |
| title_full_unstemmed | Transcranial magnetic stimulation set-up for small animals |
| title_short | Transcranial magnetic stimulation set-up for small animals |
| title_sort | transcranial magnetic stimulation set up for small animals |
| topic | transcranial magnetic stimulation TMS coil holder electromyography rat |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.935268/full |
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