Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients
Burns not only damage the skin barrier, but also cause a series of inflammatory reactions and oxidative stress states. Among them, elderly patients are prone to suffer severe burns due to degenerative changes of their skin caused by aging factors, such as atrophy and thinning, etc. After burns, the...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-01-01
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| Series: | Smart Materials in Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590183422000394 |
| _version_ | 1797774810178125824 |
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| author | Wei Xiong Rui Zhang Heng Zhou Ye Liu Ming Liang Keshen Li Xingxiang Duan David Pengcheng Chen Yu Luo Jia Xu Yilong Ai Yan He Qingsong Ye |
| author_facet | Wei Xiong Rui Zhang Heng Zhou Ye Liu Ming Liang Keshen Li Xingxiang Duan David Pengcheng Chen Yu Luo Jia Xu Yilong Ai Yan He Qingsong Ye |
| author_sort | Wei Xiong |
| collection | DOAJ |
| description | Burns not only damage the skin barrier, but also cause a series of inflammatory reactions and oxidative stress states. Among them, elderly patients are prone to suffer severe burns due to degenerative changes of their skin caused by aging factors, such as atrophy and thinning, etc. After burns, the body will continuously release inflammatory factors, resulting in systemic inflammatory response syndrome (SIRS) and oxidative stress, which are related to the poor treatment effect and the poor prognosis of elderly burn patients. It seems to be difficult for conventional treatments to control the disease development of elderly burn patients effectively. Considering the rapidly increasing elderly population, it is priority to understand the pathological process and the mechanisms to formulate more appropriate treatment strategies for elderly burn patients. In recent years, owing to considerable advances in nanotechnology, a variety of nanomaterials have been developed for wound healing and inflammation regulation. Its good biocompatibility, cell proliferation stimulation and antibacterial properties make the clinical treatment strategy more optimized. Concurrently, mesenchymal stem cells (MSCs) have also been used in the burns field and have been proven effective in not only controlling the level of inflammation and regulating the systemic immune balance, but also promoting wound healing and vascularization. Here, this review covers burns classification, the pathological process of elderly burn patients, and the research progress of nanotechnology and MSCs in burns. Eventually, we summarize the advantages and challenges of emerging strategies such as nanotechnology and MSCs in the treatment of elderly burn patients, expecting to promote the clinical transformation. |
| first_indexed | 2024-03-12T22:26:36Z |
| format | Article |
| id | doaj.art-586abd6c4bbd4616ad7c0952e228a1bd |
| institution | Directory Open Access Journal |
| issn | 2590-1834 |
| language | English |
| last_indexed | 2024-03-12T22:26:36Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Smart Materials in Medicine |
| spelling | doaj.art-586abd6c4bbd4616ad7c0952e228a1bd2023-07-22T04:52:39ZengKeAi Communications Co., Ltd.Smart Materials in Medicine2590-18342023-01-0147890Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patientsWei Xiong0Rui Zhang1Heng Zhou2Ye Liu3Ming Liang4Keshen Li5Xingxiang Duan6David Pengcheng Chen7Yu Luo8Jia Xu9Yilong Ai10Yan He11Qingsong Ye12Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, ChinaInstitute of Regenerative and Translational Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, ChinaInstitute of Regenerative and Translational Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, ChinaSchool of Dentistry, University of Queensland, Herston, 4006, QLD, AustraliaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, ChinaSchool of Environment and Science, Griffith University, Nathan, QLD, 4111, AustraliaFoshan Hospital of Stomatology, School of Medicine, Foshan University, Foshan, ChinaInstitute of Regenerative and Translational Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, China; Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, USA; Corresponding author. Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, China.Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, China; Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, USA; Corresponding author. Institute of Regenerative and Translational Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, China.Burns not only damage the skin barrier, but also cause a series of inflammatory reactions and oxidative stress states. Among them, elderly patients are prone to suffer severe burns due to degenerative changes of their skin caused by aging factors, such as atrophy and thinning, etc. After burns, the body will continuously release inflammatory factors, resulting in systemic inflammatory response syndrome (SIRS) and oxidative stress, which are related to the poor treatment effect and the poor prognosis of elderly burn patients. It seems to be difficult for conventional treatments to control the disease development of elderly burn patients effectively. Considering the rapidly increasing elderly population, it is priority to understand the pathological process and the mechanisms to formulate more appropriate treatment strategies for elderly burn patients. In recent years, owing to considerable advances in nanotechnology, a variety of nanomaterials have been developed for wound healing and inflammation regulation. Its good biocompatibility, cell proliferation stimulation and antibacterial properties make the clinical treatment strategy more optimized. Concurrently, mesenchymal stem cells (MSCs) have also been used in the burns field and have been proven effective in not only controlling the level of inflammation and regulating the systemic immune balance, but also promoting wound healing and vascularization. Here, this review covers burns classification, the pathological process of elderly burn patients, and the research progress of nanotechnology and MSCs in burns. Eventually, we summarize the advantages and challenges of emerging strategies such as nanotechnology and MSCs in the treatment of elderly burn patients, expecting to promote the clinical transformation.http://www.sciencedirect.com/science/article/pii/S2590183422000394Burn injuryAging peoplePathological processNanotechnologyMesenchymal stem cellsWound healing |
| spellingShingle | Wei Xiong Rui Zhang Heng Zhou Ye Liu Ming Liang Keshen Li Xingxiang Duan David Pengcheng Chen Yu Luo Jia Xu Yilong Ai Yan He Qingsong Ye Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients Smart Materials in Medicine Burn injury Aging people Pathological process Nanotechnology Mesenchymal stem cells Wound healing |
| title | Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients |
| title_full | Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients |
| title_fullStr | Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients |
| title_full_unstemmed | Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients |
| title_short | Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients |
| title_sort | application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients |
| topic | Burn injury Aging people Pathological process Nanotechnology Mesenchymal stem cells Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2590183422000394 |
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