The Role of microRNAs in Inflammation
Inflammation is a biological response of the immune system to various insults, such as pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro- and anti-inflammatory factors and their direction towards inflammation often leads to the development and progression of variou...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/24/15479 |
| _version_ | 1797457324447629312 |
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| author | Kaushik Das L. Vijaya Mohan Rao |
| author_facet | Kaushik Das L. Vijaya Mohan Rao |
| author_sort | Kaushik Das |
| collection | DOAJ |
| description | Inflammation is a biological response of the immune system to various insults, such as pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro- and anti-inflammatory factors and their direction towards inflammation often leads to the development and progression of various inflammation-associated diseases. The role of small non-coding RNAs (small ncRNAs) in inflammation has gained much attention in the past two decades for their regulation of inflammatory gene expression at multiple levels and their potential to serve as biomarkers and therapeutic targets in various diseases. One group of small ncRNAs, microRNAs (miRNAs), has become a key regulator in various inflammatory disease conditions. Their fine-tuning of target gene regulation often turns out to be an important factor in controlling aberrant inflammatory reactions in the system. This review summarizes the biogenesis of miRNA and the mechanisms of miRNA-mediated gene regulation. The review also briefly discusses various pro- and anti-inflammatory miRNAs, their targets and functions, and provides a detailed discussion on the role of miR-10a in inflammation. |
| first_indexed | 2024-03-09T16:20:37Z |
| format | Article |
| id | doaj.art-586bf325ac3d4900ab0a2a0873f5a36d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:20:37Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-586bf325ac3d4900ab0a2a0873f5a36d2023-11-24T15:22:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241547910.3390/ijms232415479The Role of microRNAs in InflammationKaushik Das0L. Vijaya Mohan Rao1Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USADepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USAInflammation is a biological response of the immune system to various insults, such as pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro- and anti-inflammatory factors and their direction towards inflammation often leads to the development and progression of various inflammation-associated diseases. The role of small non-coding RNAs (small ncRNAs) in inflammation has gained much attention in the past two decades for their regulation of inflammatory gene expression at multiple levels and their potential to serve as biomarkers and therapeutic targets in various diseases. One group of small ncRNAs, microRNAs (miRNAs), has become a key regulator in various inflammatory disease conditions. Their fine-tuning of target gene regulation often turns out to be an important factor in controlling aberrant inflammatory reactions in the system. This review summarizes the biogenesis of miRNA and the mechanisms of miRNA-mediated gene regulation. The review also briefly discusses various pro- and anti-inflammatory miRNAs, their targets and functions, and provides a detailed discussion on the role of miR-10a in inflammation.https://www.mdpi.com/1422-0067/23/24/15479inflammationmicroRNAsmall non-coding RNA |
| spellingShingle | Kaushik Das L. Vijaya Mohan Rao The Role of microRNAs in Inflammation International Journal of Molecular Sciences inflammation microRNA small non-coding RNA |
| title | The Role of microRNAs in Inflammation |
| title_full | The Role of microRNAs in Inflammation |
| title_fullStr | The Role of microRNAs in Inflammation |
| title_full_unstemmed | The Role of microRNAs in Inflammation |
| title_short | The Role of microRNAs in Inflammation |
| title_sort | role of micrornas in inflammation |
| topic | inflammation microRNA small non-coding RNA |
| url | https://www.mdpi.com/1422-0067/23/24/15479 |
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