Adjuvant Chinese Medicine for the Treatment of Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of a Randomised Controlled Trial
Mild cognitive impairment has a high prevalence in the type 2 diabetic population. Adjuvant therapy with Chinese herbal medicine can effectively improve the clinical symptoms of patients with T2DM combined with MCI. The aim of this study was to systematically evaluate the efficacy and safety of Chin...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/11/1424 |
| _version_ | 1797464219774353408 |
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| author | Changxing Liu Xinyi Guo |
| author_facet | Changxing Liu Xinyi Guo |
| author_sort | Changxing Liu |
| collection | DOAJ |
| description | Mild cognitive impairment has a high prevalence in the type 2 diabetic population. Adjuvant therapy with Chinese herbal medicine can effectively improve the clinical symptoms of patients with T2DM combined with MCI. The aim of this study was to systematically evaluate the efficacy and safety of Chinese herbal adjunctive therapy in the treatment of diabetes mellitus combined with cognitive impairment. Information was analysed using the China Knowledge Network, Vip Database, Wanfang Database, China Biomedical Literature Database, PubMed, EMbase, Web of Science, and MedLine Database. The total clinical efficiency, blood glucose, blood lipids, Simple Mental-State Examination Scale (MMSE), Montreal Cognitive Assessment Scale (MoCA), Traditional Chinese Medicine Symptom Score (TCMSS), and incidence of adverse reactions were recorded. The methodological quality of the included studies was evaluated using the application of the Cochrane Collaboration Network Risk Bias Assessment Tool, and meta-analysis was performed using RevMan 5.4 software. Adjuvant treatment with Chinese herbal medicine was effective in improving the clinical outcomes (OR = 5.33, 95% CI (3.62, 7.84), <i>p</i> < 0.00001) and cognitive function by comparing with the control group: MMSE (MD = 1.56, 95% CI (1.29, 1.84), <i>p</i> < 0.00001) and MoCA (MD = 2.77, 95% CI (1.81, 3.73), <i>p</i> < 0.0001); lowered blood glucose: fasting blood glucose (FBG) (MD = −0.27, 95% CI (−0.42, −0.12), <i>p</i> = 0.0006), 2 hPG (MD = −0.28, 95% CI (−0.45, −0.10), <i>p</i> = 0.002), and glycated haemoglobin (HbA1c) (MD = −0.26, 95% CI (−0.39, −0.14), <i>p</i> < 0.001); and improved lipids: total cholesterol (TC) (MD = −0.51, 95% CI (−0.82, −0.21), <i>p</i> = 0.001), triglycerides (TGs) (MD = −0.46, 95% CI −0.46, 95% CI (−0.80, −0.11), <i>p</i> = 0.009), low-density lipoprotein (LDL-C) (MD = −0.28, 95% CI (−0.55, −0.02), <i>p</i> = 0.04), high-density lipoprotein (HDL-C) (MD = 0.17, 95% CI (0.07, 0.28), <i>p</i> = 0.001), reduced TCMSS (MD = −1.84, 95% CI (−2.58, −1.10), <i>p</i> < 0.0001), and incidence of adverse events (OR = 0.46, 95% CI (0.24, 0.88), <i>p</i> = 0.02). In conclusion, through the available evidence, herbal adjuvant therapy for T2DM combined with MCI was observed to be effective and did not significantly increase the adverse effects. Due to the limitation of the number and quality of the included studies, the abovementioned results need to be validated by further high-quality studies. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-09T18:04:38Z |
| publishDate | 2022-11-01 |
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| series | Pharmaceuticals |
| spelling | doaj.art-586c07e54b024776853fa4c5a26ea38a2023-11-24T09:35:30ZengMDPI AGPharmaceuticals1424-82472022-11-011511142410.3390/ph15111424Adjuvant Chinese Medicine for the Treatment of Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of a Randomised Controlled TrialChangxing Liu0Xinyi Guo1Department of Integrative Medicine of the First Clinical Medical College, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, ChinaDepartment of Integrative Medicine of the First Clinical Medical College, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, ChinaMild cognitive impairment has a high prevalence in the type 2 diabetic population. Adjuvant therapy with Chinese herbal medicine can effectively improve the clinical symptoms of patients with T2DM combined with MCI. The aim of this study was to systematically evaluate the efficacy and safety of Chinese herbal adjunctive therapy in the treatment of diabetes mellitus combined with cognitive impairment. Information was analysed using the China Knowledge Network, Vip Database, Wanfang Database, China Biomedical Literature Database, PubMed, EMbase, Web of Science, and MedLine Database. The total clinical efficiency, blood glucose, blood lipids, Simple Mental-State Examination Scale (MMSE), Montreal Cognitive Assessment Scale (MoCA), Traditional Chinese Medicine Symptom Score (TCMSS), and incidence of adverse reactions were recorded. The methodological quality of the included studies was evaluated using the application of the Cochrane Collaboration Network Risk Bias Assessment Tool, and meta-analysis was performed using RevMan 5.4 software. Adjuvant treatment with Chinese herbal medicine was effective in improving the clinical outcomes (OR = 5.33, 95% CI (3.62, 7.84), <i>p</i> < 0.00001) and cognitive function by comparing with the control group: MMSE (MD = 1.56, 95% CI (1.29, 1.84), <i>p</i> < 0.00001) and MoCA (MD = 2.77, 95% CI (1.81, 3.73), <i>p</i> < 0.0001); lowered blood glucose: fasting blood glucose (FBG) (MD = −0.27, 95% CI (−0.42, −0.12), <i>p</i> = 0.0006), 2 hPG (MD = −0.28, 95% CI (−0.45, −0.10), <i>p</i> = 0.002), and glycated haemoglobin (HbA1c) (MD = −0.26, 95% CI (−0.39, −0.14), <i>p</i> < 0.001); and improved lipids: total cholesterol (TC) (MD = −0.51, 95% CI (−0.82, −0.21), <i>p</i> = 0.001), triglycerides (TGs) (MD = −0.46, 95% CI −0.46, 95% CI (−0.80, −0.11), <i>p</i> = 0.009), low-density lipoprotein (LDL-C) (MD = −0.28, 95% CI (−0.55, −0.02), <i>p</i> = 0.04), high-density lipoprotein (HDL-C) (MD = 0.17, 95% CI (0.07, 0.28), <i>p</i> = 0.001), reduced TCMSS (MD = −1.84, 95% CI (−2.58, −1.10), <i>p</i> < 0.0001), and incidence of adverse events (OR = 0.46, 95% CI (0.24, 0.88), <i>p</i> = 0.02). In conclusion, through the available evidence, herbal adjuvant therapy for T2DM combined with MCI was observed to be effective and did not significantly increase the adverse effects. Due to the limitation of the number and quality of the included studies, the abovementioned results need to be validated by further high-quality studies.https://www.mdpi.com/1424-8247/15/11/1424diabetes mellituscognitive impairmentChinese herbal medicinesystematic reviewmeta-analysis |
| spellingShingle | Changxing Liu Xinyi Guo Adjuvant Chinese Medicine for the Treatment of Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of a Randomised Controlled Trial Pharmaceuticals diabetes mellitus cognitive impairment Chinese herbal medicine systematic review meta-analysis |
| title | Adjuvant Chinese Medicine for the Treatment of Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of a Randomised Controlled Trial |
| title_full | Adjuvant Chinese Medicine for the Treatment of Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of a Randomised Controlled Trial |
| title_fullStr | Adjuvant Chinese Medicine for the Treatment of Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of a Randomised Controlled Trial |
| title_full_unstemmed | Adjuvant Chinese Medicine for the Treatment of Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of a Randomised Controlled Trial |
| title_short | Adjuvant Chinese Medicine for the Treatment of Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of a Randomised Controlled Trial |
| title_sort | adjuvant chinese medicine for the treatment of type 2 diabetes mellitus combined with mild cognitive impairment a systematic review and meta analysis of a randomised controlled trial |
| topic | diabetes mellitus cognitive impairment Chinese herbal medicine systematic review meta-analysis |
| url | https://www.mdpi.com/1424-8247/15/11/1424 |
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