Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan
BackgroundMultiple sclerosis, a chronic inflammatory disease in young and middle-aged adults, is one of the leading causes of non-traumatic disability in adults. Diet is known to have an important role in the modulating inflammatory processes and influencing molecular pathways.PurposeThis study aims...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1098883/full |
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| author | Omar A. Alhaj Khaled Trabelsi Abdallah M. Younes Nitin Shivappa Nitin Shivappa Nitin Shivappa Nicola L. Bragazzi Nicola L. Bragazzi James R. Hebert James R. Hebert James R. Hebert Haitham A. Jahrami Haitham A. Jahrami |
| author_facet | Omar A. Alhaj Khaled Trabelsi Abdallah M. Younes Nitin Shivappa Nitin Shivappa Nitin Shivappa Nicola L. Bragazzi Nicola L. Bragazzi James R. Hebert James R. Hebert James R. Hebert Haitham A. Jahrami Haitham A. Jahrami |
| author_sort | Omar A. Alhaj |
| collection | DOAJ |
| description | BackgroundMultiple sclerosis, a chronic inflammatory disease in young and middle-aged adults, is one of the leading causes of non-traumatic disability in adults. Diet is known to have an important role in the modulating inflammatory processes and influencing molecular pathways.PurposeThis study aims to examine the association of the inflammatory capacity of diet measured by DII with MS in Jordan.MethodsThis prevalent case-control study included participants of both sexes, aged between 20 and 60 years. The cases (n = 541) had a confirmed diagnosis of prevalent Multiple Sclerosis (MS) in the previous 3 years, and controls (n = 607) were apparently healthy individuals matched on sex and age (42 ± 4 years). A validated Arabic food frequency questionnaire (FFQ) was utilized to obtain estimated dietary intake. Dietary data from the FFQ were analyzed using ESHA’s Food Processor® nutrition analysis software, and the results were used to calculate the DII scores. Logistic regression analyses, controlling for covariates such as age, sex, body mass index, and smoking status, were used to measure the association between DII score and MS outcomes.ResultsCases represent a mixed sample of MS phenotypes and controls were comparable on age and sex. However, controls tended to be taller, lighter, had a lower BMI, and had a lower smoking rate. After controlling for age, BMI, sex, and smoking status, there was a consistent increase in MS risk according to DII score, with a 10-fold increase in odds in quartile 4 vs. quartile 1 [ORquartile 4vs1 = 10.17 (95% CI: 6.88; 15.04)]. For each point increase in DII score, there was nearly a doubling of odds [OR1 = 1.75 (95% CI: 1.59; 1.92)]. Individual nutrients and food values aligned according to their contribution to the DII score calculations.ConclusionThe findings of this study, obtained in MS patients with varied illness duration over the previous 3 years, are consistent with an association between the overall inflammatory potential of diet and MS odds. Our findings among MS participants showed a significantly more pro-inflammatory DII scores than age- and sex-matched controls. Our results also suggest that MS group had a diet rich in pro-inflammatory foods and nutrients. |
| first_indexed | 2024-04-09T19:28:48Z |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-09T19:28:48Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-586d4b7114a149a081a36e2b63be7fd52023-04-05T05:25:54ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-04-011010.3389/fnut.2023.10988831098883Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in JordanOmar A. Alhaj0Khaled Trabelsi1Abdallah M. Younes2Nitin Shivappa3Nitin Shivappa4Nitin Shivappa5Nicola L. Bragazzi6Nicola L. Bragazzi7James R. Hebert8James R. Hebert9James R. Hebert10Haitham A. Jahrami11Haitham A. Jahrami12Department of Nutrition, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, JordanHigh Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, TunisiaConsultant Neurologist, Amman, JordanDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, United StatesThe Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, United StatesDepartment of Nutrition, Connecting Health Innovations LLC, Columbia, SC, United StatesLaboratory for Industrial and Applied Mathematics, Department of Statistics, York University, Toronto, ON, CanadaHuman Nutrition Unit, Department of Food and Drugs, University of Parma Medical School, Parma, ItalyDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, United StatesThe Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, United StatesDepartment of Nutrition, Connecting Health Innovations LLC, Columbia, SC, United StatesDepartment of Psychiatry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain0Ministry of Health, Government Hospitals, Manama, BahrainBackgroundMultiple sclerosis, a chronic inflammatory disease in young and middle-aged adults, is one of the leading causes of non-traumatic disability in adults. Diet is known to have an important role in the modulating inflammatory processes and influencing molecular pathways.PurposeThis study aims to examine the association of the inflammatory capacity of diet measured by DII with MS in Jordan.MethodsThis prevalent case-control study included participants of both sexes, aged between 20 and 60 years. The cases (n = 541) had a confirmed diagnosis of prevalent Multiple Sclerosis (MS) in the previous 3 years, and controls (n = 607) were apparently healthy individuals matched on sex and age (42 ± 4 years). A validated Arabic food frequency questionnaire (FFQ) was utilized to obtain estimated dietary intake. Dietary data from the FFQ were analyzed using ESHA’s Food Processor® nutrition analysis software, and the results were used to calculate the DII scores. Logistic regression analyses, controlling for covariates such as age, sex, body mass index, and smoking status, were used to measure the association between DII score and MS outcomes.ResultsCases represent a mixed sample of MS phenotypes and controls were comparable on age and sex. However, controls tended to be taller, lighter, had a lower BMI, and had a lower smoking rate. After controlling for age, BMI, sex, and smoking status, there was a consistent increase in MS risk according to DII score, with a 10-fold increase in odds in quartile 4 vs. quartile 1 [ORquartile 4vs1 = 10.17 (95% CI: 6.88; 15.04)]. For each point increase in DII score, there was nearly a doubling of odds [OR1 = 1.75 (95% CI: 1.59; 1.92)]. Individual nutrients and food values aligned according to their contribution to the DII score calculations.ConclusionThe findings of this study, obtained in MS patients with varied illness duration over the previous 3 years, are consistent with an association between the overall inflammatory potential of diet and MS odds. Our findings among MS participants showed a significantly more pro-inflammatory DII scores than age- and sex-matched controls. Our results also suggest that MS group had a diet rich in pro-inflammatory foods and nutrients.https://www.frontiersin.org/articles/10.3389/fnut.2023.1098883/fulldietary inflammatory index (DII)nutritionmultiple sclerosismacronutrientsmicronutrients |
| spellingShingle | Omar A. Alhaj Khaled Trabelsi Abdallah M. Younes Nitin Shivappa Nitin Shivappa Nitin Shivappa Nicola L. Bragazzi Nicola L. Bragazzi James R. Hebert James R. Hebert James R. Hebert Haitham A. Jahrami Haitham A. Jahrami Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan Frontiers in Nutrition dietary inflammatory index (DII) nutrition multiple sclerosis macronutrients micronutrients |
| title | Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan |
| title_full | Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan |
| title_fullStr | Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan |
| title_full_unstemmed | Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan |
| title_short | Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan |
| title_sort | diet related inflammation increases the odds of multiple sclerosis results from a large population based prevalent case control study in jordan |
| topic | dietary inflammatory index (DII) nutrition multiple sclerosis macronutrients micronutrients |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1098883/full |
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