Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia
Background: Preeclampsia is a serious complication of pregnancy with negative consequences for the mother and fetus. It was aimed to investigate whether the systemic immune inflammation index is a parameter that will facilitate the diagnosis of preeclampsia. Methods: This retrospective and single-ce...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024042129 |
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| author | Mucahit Kapci Kemal Sener Adem Cakir Ertugrul Altug Ramazan Guven Akkan Avci |
| author_facet | Mucahit Kapci Kemal Sener Adem Cakir Ertugrul Altug Ramazan Guven Akkan Avci |
| author_sort | Mucahit Kapci |
| collection | DOAJ |
| description | Background: Preeclampsia is a serious complication of pregnancy with negative consequences for the mother and fetus. It was aimed to investigate whether the systemic immune inflammation index is a parameter that will facilitate the diagnosis of preeclampsia. Methods: This retrospective and single-center study included patients diagnosed with preeclampsia after admission to the emergency department and those who met the inclusion criteria. Vital parameters, demographic data, medical history, white blood cell count, platelet count, neutrophil count, systemic immune-inflammation index values, biochemical parameters, and gestational weeks were analyzed in each patient. Results: A total of 40 patients with preeclampsia (preeclampsia group) and 40 normal pregnant women (control group) were included. Laboratory tests revealed that the mean WBC, neutrophil, and lymphocyte counts were significantly higher in the preeclampsia group than in the control group, whereas the preeclampsia group had a significantly lower mean platelet count than the control group (p < 0.001). The sensitivity and specificity for the cut-off value of 758.39 × 109/L systemic immune-inflammation index in pregnant patients with preeclampsia was 77.5% and 67.5%, respectively (AUC: 0.705; 95% CI: 0.587–0.823; p = 0.002). No significant difference was observed between the mean neutrophil-to-lymphocyte ratio in preeclampsia diagnosis. Conclusion: The systemic immune-inflammation index may be used as a marker to help in establishing the diagnosis of preeclampsia. We believe that this index is an important prognostic indicator because it concurrently evaluates neutrophil and lymphocyte values—which indicate the inflammation process—and platelet count, i.e., an indicator of coagulopathy. |
| first_indexed | 2024-04-24T13:48:10Z |
| format | Article |
| id | doaj.art-586d7ffa238646b79aa2cadc54dec4cf |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:48:10Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-586d7ffa238646b79aa2cadc54dec4cf2024-04-04T05:06:59ZengElsevierHeliyon2405-84402024-03-01106e28181Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsiaMucahit Kapci0Kemal Sener1Adem Cakir2Ertugrul Altug3Ramazan Guven4Akkan Avci5Department of Emergence Medicine, Republic of Turkey, Ministry of Healthy Başaksehir Çam and Sakura State Hospital, Istanbul, Turkey; Corresponding author.Department of Emergence Medicine, Republic of Turkey, Mersin State Training and Research Hospital Hospital, Mersin, TurkeyDepartment of Emergency Medicine, Ministry of Health of Turkey, Canakkale Mehmet Akif Ersoy State Hospital, Canakkale, TurkeyDepartment of Emergence Medicine, Republic of Turkey, Ministry of Healthy Başaksehir Çam and Sakura State Hospital, Istanbul, TurkeyDepartment of Emergence Medicine, Republic of Turkey, Ministry of Healthy Başaksehir Çam and Sakura State Hospital, Istanbul, TurkeyHealth Science University, Adana City Research and Training Hospital, Department of Emergency Medicine, Adana, TurkeyBackground: Preeclampsia is a serious complication of pregnancy with negative consequences for the mother and fetus. It was aimed to investigate whether the systemic immune inflammation index is a parameter that will facilitate the diagnosis of preeclampsia. Methods: This retrospective and single-center study included patients diagnosed with preeclampsia after admission to the emergency department and those who met the inclusion criteria. Vital parameters, demographic data, medical history, white blood cell count, platelet count, neutrophil count, systemic immune-inflammation index values, biochemical parameters, and gestational weeks were analyzed in each patient. Results: A total of 40 patients with preeclampsia (preeclampsia group) and 40 normal pregnant women (control group) were included. Laboratory tests revealed that the mean WBC, neutrophil, and lymphocyte counts were significantly higher in the preeclampsia group than in the control group, whereas the preeclampsia group had a significantly lower mean platelet count than the control group (p < 0.001). The sensitivity and specificity for the cut-off value of 758.39 × 109/L systemic immune-inflammation index in pregnant patients with preeclampsia was 77.5% and 67.5%, respectively (AUC: 0.705; 95% CI: 0.587–0.823; p = 0.002). No significant difference was observed between the mean neutrophil-to-lymphocyte ratio in preeclampsia diagnosis. Conclusion: The systemic immune-inflammation index may be used as a marker to help in establishing the diagnosis of preeclampsia. We believe that this index is an important prognostic indicator because it concurrently evaluates neutrophil and lymphocyte values—which indicate the inflammation process—and platelet count, i.e., an indicator of coagulopathy.http://www.sciencedirect.com/science/article/pii/S2405844024042129PreeclampsiaSystemic immune-inflammation indexPlatelet countNeutrophil-to-lymphocyte ratio |
| spellingShingle | Mucahit Kapci Kemal Sener Adem Cakir Ertugrul Altug Ramazan Guven Akkan Avci Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia Heliyon Preeclampsia Systemic immune-inflammation index Platelet count Neutrophil-to-lymphocyte ratio |
| title | Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia |
| title_full | Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia |
| title_fullStr | Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia |
| title_full_unstemmed | Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia |
| title_short | Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia |
| title_sort | prognostic value of systemic immune inflammation index in the diagnosis of preeclampsia |
| topic | Preeclampsia Systemic immune-inflammation index Platelet count Neutrophil-to-lymphocyte ratio |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024042129 |
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