ICAM-5 affects spine maturation by regulation of NMDA receptor binding to α-actinin

ICAM-5 affects spine maturation by regulation of NMDA receptor binding to α-actinin

ICAM-5 is a negative regulator of dendritic spine maturation and facilitates the formation of filopodia. Its absence results in improved memory functions, but the mechanisms have remained poorly understood. Activation of NMDA receptors induces ICAM-5 ectodomain cleavage through a matrix metalloprote...

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Bibliographic Details
Main Authors: Lin Ning, Sonja Paetau, Henrietta Nyman-Huttunen, Li Tian, Carl G. Gahmberg
Format: Article
Language:English
Published: The Company of Biologists 2015-01-01
Series:Biology Open
Subjects:
ICAM-5
Integrin
Actinin
Cell adhesion
Spine maturation
Online Access:http://bio.biologists.org/content/4/2/125

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