The Effect of Age on Prostate Cancer Survival
It is not clear to what extent the age of diagnosis and the attained age impact on cancer mortality rates in men with newly diagnosed prostate cancer. We estimated annual prostate cancer mortality rates and 20-year survival rates according to the age of diagnosis, race, grade and time since diagnosi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/17/4149 |
| _version_ | 1797496097065664512 |
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| author | Roderick Clark Danny Vesprini Steven A. Narod |
| author_facet | Roderick Clark Danny Vesprini Steven A. Narod |
| author_sort | Roderick Clark |
| collection | DOAJ |
| description | It is not clear to what extent the age of diagnosis and the attained age impact on cancer mortality rates in men with newly diagnosed prostate cancer. We estimated annual prostate cancer mortality rates and 20-year survival rates according to the age of diagnosis, race, grade and time since diagnosis using data from the Surveillance, Epidemiology and End-Results (SEER) program. We identified 116,796 prostate cancer patients diagnosed between 1992 and 1997 and followed them for 20 years. There were 21,896 deaths from prostate cancer. We calculated actuarial survival rates and annual prostate cancer mortality rates by age of diagnosis and by tumor grade. The risk of a man dying of prostate cancer was 17% for men diagnosed before age 70 and was 21% for those diagnosed after age 70. The mean annual prostate cancer mortality rate calculated over the 20-year period post-diagnosis was 1.5%. The annual rate increased from 0.9% for those diagnosed below age 60 to 2.1% for those diagnosed above age 70. For men with Gleason score ≥ 7 prostate cancer, the annual prostate cancer mortality rate peaked 2–3 years after diagnosis and then declined. For men diagnosed with Gleason score ≤ 6 prostate cancer, the annual prostate cancer mortality rate continued to rise 20 years after diagnosis and peaked after age 85. This suggests that high-grade prostate cancers are aggressive from the outset, but that low-grade prostate cancers may enter a state of dormancy and reactivate as the patient ages. |
| first_indexed | 2024-03-10T01:58:48Z |
| format | Article |
| id | doaj.art-586e01fb3a5844b59074bd1a8aa7b4e7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:58:48Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-586e01fb3a5844b59074bd1a8aa7b4e72023-11-23T12:50:39ZengMDPI AGCancers2072-66942022-08-011417414910.3390/cancers14174149The Effect of Age on Prostate Cancer SurvivalRoderick Clark0Danny Vesprini1Steven A. Narod2Division of Urology, Department of Surgery, University of Toronto, Toronto, ON M5G 2C4, CanadaDepartment of Radiation Oncology, University of Toronto, Toronto, ON M5T 1P5, CanadaWomen’s College Research Institute, Women’s College Hospital, Toronto, ON M5S 1B2, CanadaIt is not clear to what extent the age of diagnosis and the attained age impact on cancer mortality rates in men with newly diagnosed prostate cancer. We estimated annual prostate cancer mortality rates and 20-year survival rates according to the age of diagnosis, race, grade and time since diagnosis using data from the Surveillance, Epidemiology and End-Results (SEER) program. We identified 116,796 prostate cancer patients diagnosed between 1992 and 1997 and followed them for 20 years. There were 21,896 deaths from prostate cancer. We calculated actuarial survival rates and annual prostate cancer mortality rates by age of diagnosis and by tumor grade. The risk of a man dying of prostate cancer was 17% for men diagnosed before age 70 and was 21% for those diagnosed after age 70. The mean annual prostate cancer mortality rate calculated over the 20-year period post-diagnosis was 1.5%. The annual rate increased from 0.9% for those diagnosed below age 60 to 2.1% for those diagnosed above age 70. For men with Gleason score ≥ 7 prostate cancer, the annual prostate cancer mortality rate peaked 2–3 years after diagnosis and then declined. For men diagnosed with Gleason score ≤ 6 prostate cancer, the annual prostate cancer mortality rate continued to rise 20 years after diagnosis and peaked after age 85. This suggests that high-grade prostate cancers are aggressive from the outset, but that low-grade prostate cancers may enter a state of dormancy and reactivate as the patient ages.https://www.mdpi.com/2072-6694/14/17/4149prostate cancermortalityepidemiology |
| spellingShingle | Roderick Clark Danny Vesprini Steven A. Narod The Effect of Age on Prostate Cancer Survival Cancers prostate cancer mortality epidemiology |
| title | The Effect of Age on Prostate Cancer Survival |
| title_full | The Effect of Age on Prostate Cancer Survival |
| title_fullStr | The Effect of Age on Prostate Cancer Survival |
| title_full_unstemmed | The Effect of Age on Prostate Cancer Survival |
| title_short | The Effect of Age on Prostate Cancer Survival |
| title_sort | effect of age on prostate cancer survival |
| topic | prostate cancer mortality epidemiology |
| url | https://www.mdpi.com/2072-6694/14/17/4149 |
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