Immunological evidence for the presence of B protein (apoprotein of Β-lipoprotein) in normal and abetalipoproteinemic plasma
The antigenicity of Β-lipoprotein that had been chemically altered by acetylation or arsanilation was compared with that of native Β-lipoprotein, of lymph chylomicrons, of plasma proteins with d > 1.21, and of plasma from patients with abetalipoproteinemia. Chemical alteration causes structural c...
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| Format: | Article |
| Language: | English |
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Elsevier
1967-07-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520395729 |
| _version_ | 1818925649414324224 |
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| author | Robert S. Lees |
| author_facet | Robert S. Lees |
| author_sort | Robert S. Lees |
| collection | DOAJ |
| description | The antigenicity of Β-lipoprotein that had been chemically altered by acetylation or arsanilation was compared with that of native Β-lipoprotein, of lymph chylomicrons, of plasma proteins with d > 1.21, and of plasma from patients with abetalipoproteinemia. Chemical alteration causes structural changes in Β-lipoprotein which render it immunologically identical with a protein that is present both in normal plasma and in plasma from patients with abetalipoproteinemia. This protein has been identified by immunoelectrophoresis as a Β-globulin which does not stain for lipid. It is presumed to be the lipid-free apoprotein of Β-lipoprotein (B protein).The findings suggest that abetalipoproteinemia is not due to inability to synthesize B protein, but might instead be due to a defect in the formation of the complete Β-lipoprotein macromolecule. |
| first_indexed | 2024-12-20T02:44:35Z |
| format | Article |
| id | doaj.art-586e4a73d50b40c1af8b1b422e004351 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-20T02:44:35Z |
| publishDate | 1967-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-586e4a73d50b40c1af8b1b422e0043512022-12-21T19:56:13ZengElsevierJournal of Lipid Research0022-22751967-07-0184396405Immunological evidence for the presence of B protein (apoprotein of Β-lipoprotein) in normal and abetalipoproteinemic plasmaRobert S. Lees0The Rockefeller University, New York 10021The antigenicity of Β-lipoprotein that had been chemically altered by acetylation or arsanilation was compared with that of native Β-lipoprotein, of lymph chylomicrons, of plasma proteins with d > 1.21, and of plasma from patients with abetalipoproteinemia. Chemical alteration causes structural changes in Β-lipoprotein which render it immunologically identical with a protein that is present both in normal plasma and in plasma from patients with abetalipoproteinemia. This protein has been identified by immunoelectrophoresis as a Β-globulin which does not stain for lipid. It is presumed to be the lipid-free apoprotein of Β-lipoprotein (B protein).The findings suggest that abetalipoproteinemia is not due to inability to synthesize B protein, but might instead be due to a defect in the formation of the complete Β-lipoprotein macromolecule.http://www.sciencedirect.com/science/article/pii/S0022227520395729Β-lipoproteinazo-Β-lipoproteinacetyl-Β-lipoproteinantiseraB proteinplasma 1.21 infranate |
| spellingShingle | Robert S. Lees Immunological evidence for the presence of B protein (apoprotein of Β-lipoprotein) in normal and abetalipoproteinemic plasma Journal of Lipid Research Β-lipoprotein azo-Β-lipoprotein acetyl-Β-lipoprotein antisera B protein plasma 1.21 infranate |
| title | Immunological evidence for the presence of B protein (apoprotein of Β-lipoprotein) in normal and abetalipoproteinemic plasma |
| title_full | Immunological evidence for the presence of B protein (apoprotein of Β-lipoprotein) in normal and abetalipoproteinemic plasma |
| title_fullStr | Immunological evidence for the presence of B protein (apoprotein of Β-lipoprotein) in normal and abetalipoproteinemic plasma |
| title_full_unstemmed | Immunological evidence for the presence of B protein (apoprotein of Β-lipoprotein) in normal and abetalipoproteinemic plasma |
| title_short | Immunological evidence for the presence of B protein (apoprotein of Β-lipoprotein) in normal and abetalipoproteinemic plasma |
| title_sort | immunological evidence for the presence of b protein apoprotein of β lipoprotein in normal and abetalipoproteinemic plasma |
| topic | Β-lipoprotein azo-Β-lipoprotein acetyl-Β-lipoprotein antisera B protein plasma 1.21 infranate |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520395729 |
| work_keys_str_mv | AT robertslees immunologicalevidenceforthepresenceofbproteinapoproteinofblipoproteininnormalandabetalipoproteinemicplasma |