Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1
Myxomatous mitral valve degeneration (MMVD) is the most common naturally occurring heart disease in dogs. There is a lack of data on antioxidant status and oxidative damage in dogs with MMVD stage B1 according to the American College of Veterinary Internal Medicine (ACVIM B1). The aim of this study...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1203480/full |
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| author | Katerina Tomsič Aleksandra Domanjko Petrič Ana Nemec Tatjana Pirman Vida Rezar Alenka Seliškar Tomaž Vovk Alenka Nemec Svete |
| author_facet | Katerina Tomsič Aleksandra Domanjko Petrič Ana Nemec Tatjana Pirman Vida Rezar Alenka Seliškar Tomaž Vovk Alenka Nemec Svete |
| author_sort | Katerina Tomsič |
| collection | DOAJ |
| description | Myxomatous mitral valve degeneration (MMVD) is the most common naturally occurring heart disease in dogs. There is a lack of data on antioxidant status and oxidative damage in dogs with MMVD stage B1 according to the American College of Veterinary Internal Medicine (ACVIM B1). The aim of this study was to investigate antioxidant status (plasma vitamin E, lipid-standardized vitamin E (LS-VitE), antioxidant capacity of lipid-(ACL) and water-soluble antioxidants, whole blood glutathione peroxidase and erythrocyte superoxide dismutase), and lipid peroxidation [malondialdehyde (MDA)] in dogs with MMVD ACVIM B1. Serum cholesterol and triglyceride concentrations were measured to calculate LS-VitE. Fourteen dogs with MMVD ACVIM B1 and 12 control dogs were included in the study. Dogs with MMVD had significantly higher vitamin E, ACL, MDA, and cholesterol concentrations and significantly higher LS-VitE values than control dogs. No significant correlations between MDA and antioxidant parameters were determined in either group. In conclusion, oxidative damage to lipids is already present and the antioxidant status is altered but not depleted in dogs with MMVD ACVIM B1. The antioxidant response to increased oxidative damage consists mainly of the activation of fat-soluble antioxidants. Further research is needed to evaluate the efficacy and targets of early antioxidant supplementation to prevent or ameliorate oxidative stress and mitigate disease progression in dogs with early-stage MMVD. |
| first_indexed | 2024-03-12T02:09:07Z |
| format | Article |
| id | doaj.art-586e4b4175a7488a82a27f7cbe34983d |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-12T02:09:07Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-586e4b4175a7488a82a27f7cbe34983d2023-09-06T17:39:23ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-09-011010.3389/fvets.2023.12034801203480Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1Katerina Tomsič0Aleksandra Domanjko Petrič1Ana Nemec2Tatjana Pirman3Vida Rezar4Alenka Seliškar5Tomaž Vovk6Alenka Nemec Svete7Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaSmall Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaSmall Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaDepartment of Animal Science, Biotechnical Faculty, University of Ljubljana, Domžale, SloveniaDepartment of Animal Science, Biotechnical Faculty, University of Ljubljana, Domžale, SloveniaSmall Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaThe Chair of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Ljubljana, Ljubljana, SloveniaSmall Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaMyxomatous mitral valve degeneration (MMVD) is the most common naturally occurring heart disease in dogs. There is a lack of data on antioxidant status and oxidative damage in dogs with MMVD stage B1 according to the American College of Veterinary Internal Medicine (ACVIM B1). The aim of this study was to investigate antioxidant status (plasma vitamin E, lipid-standardized vitamin E (LS-VitE), antioxidant capacity of lipid-(ACL) and water-soluble antioxidants, whole blood glutathione peroxidase and erythrocyte superoxide dismutase), and lipid peroxidation [malondialdehyde (MDA)] in dogs with MMVD ACVIM B1. Serum cholesterol and triglyceride concentrations were measured to calculate LS-VitE. Fourteen dogs with MMVD ACVIM B1 and 12 control dogs were included in the study. Dogs with MMVD had significantly higher vitamin E, ACL, MDA, and cholesterol concentrations and significantly higher LS-VitE values than control dogs. No significant correlations between MDA and antioxidant parameters were determined in either group. In conclusion, oxidative damage to lipids is already present and the antioxidant status is altered but not depleted in dogs with MMVD ACVIM B1. The antioxidant response to increased oxidative damage consists mainly of the activation of fat-soluble antioxidants. Further research is needed to evaluate the efficacy and targets of early antioxidant supplementation to prevent or ameliorate oxidative stress and mitigate disease progression in dogs with early-stage MMVD.https://www.frontiersin.org/articles/10.3389/fvets.2023.1203480/fullmyxomatous mitral valve degenerationantioxidant statuslipid peroxidationoxidative stressdog |
| spellingShingle | Katerina Tomsič Aleksandra Domanjko Petrič Ana Nemec Tatjana Pirman Vida Rezar Alenka Seliškar Tomaž Vovk Alenka Nemec Svete Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1 Frontiers in Veterinary Science myxomatous mitral valve degeneration antioxidant status lipid peroxidation oxidative stress dog |
| title | Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1 |
| title_full | Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1 |
| title_fullStr | Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1 |
| title_full_unstemmed | Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1 |
| title_short | Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1 |
| title_sort | evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage b1 |
| topic | myxomatous mitral valve degeneration antioxidant status lipid peroxidation oxidative stress dog |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1203480/full |
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