Remifentanil: a review of its analgesic and sedative use in the perioperative period
Adequate perioperative pain relief is an integral part of anesthesia. Opioid analgesics occupy one of the key places in the purchase of acute and chronic pain in the world. The article presents current data on the clinical effectiveness of remifentanil, a derivative of fentanyl, which is a selectiv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Interdisciplinary Academy of Pain Medicine
2024-01-01
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| Series: | Perioperative Medicine |
| Subjects: | |
| Online Access: | https://perioperative.org.ua/index.php/prtmdc/article/view/116 |
| _version_ | 1797349573131239424 |
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| author | Dmytro Dmytriiev Oleksandr Nazarchuk Yuliana Babina Kateryna Dmytriieva |
| author_facet | Dmytro Dmytriiev Oleksandr Nazarchuk Yuliana Babina Kateryna Dmytriieva |
| author_sort | Dmytro Dmytriiev |
| collection | DOAJ |
| description |
Adequate perioperative pain relief is an integral part of anesthesia. Opioid analgesics occupy one of the key places in the purchase of acute and chronic pain in the world. The article presents current data on the clinical effectiveness of remifentanil, a derivative of fentanyl, which is a selective ultra-short-acting μ-opioid receptor agonist when used in the perioperative period for the treatment of acute and chronic pain. Comparisons of the therapeutic activity and physicochemical properties, pharmacokinetic and pharmacodynamic characteristics of remifentanil with other opioids (fentanyl, sufentanil, alfentanil) are provided. Its unique properties (eg, organ function-independent metabolism, non-accumulation, rapid onset of action, and short duration of action) distinguish it from other opioid agents. Remifentanil is at least as effective as comparator opioids such as fentanyl, sufentanil in relieving pain and sedating patients during the perioperative period. In addition, it provides rapid and predictable extubation and is associated with shorter duration of mechanical ventilation and shorter length of hospitalization than comparators in some studies. In addition, remifentanil is well tolerated in both adults and children. Thus, remifentanil is a desirable addition to currently available pharmacologic agents used to treat period pain in patients
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| first_indexed | 2024-03-08T12:32:15Z |
| format | Article |
| id | doaj.art-586e5407a6fd447bb0bbe94a19b5c3e9 |
| institution | Directory Open Access Journal |
| issn | 2616-339X 2617-2925 |
| language | Russian |
| last_indexed | 2024-03-08T12:32:15Z |
| publishDate | 2024-01-01 |
| publisher | Interdisciplinary Academy of Pain Medicine |
| record_format | Article |
| series | Perioperative Medicine |
| spelling | doaj.art-586e5407a6fd447bb0bbe94a19b5c3e92024-01-21T16:01:27ZrusInterdisciplinary Academy of Pain MedicinePerioperative Medicine2616-339X2617-29252024-01-016210.31636/prmd.v6i2.2Remifentanil: a review of its analgesic and sedative use in the perioperative periodDmytro Dmytriiev0Oleksandr Nazarchuk1Yuliana Babina2Kateryna Dmytriieva3National Pirogov Memorial Medical University, Vinnytsia, UkraineNational Pirogov Memorial Medical University, Vinnytsia, UkraineNational Pirogov Memorial Medical University, Vinnytsia, UkraineNational Pirogov Memorial Medical University, Vinnytsia, Ukraine Adequate perioperative pain relief is an integral part of anesthesia. Opioid analgesics occupy one of the key places in the purchase of acute and chronic pain in the world. The article presents current data on the clinical effectiveness of remifentanil, a derivative of fentanyl, which is a selective ultra-short-acting μ-opioid receptor agonist when used in the perioperative period for the treatment of acute and chronic pain. Comparisons of the therapeutic activity and physicochemical properties, pharmacokinetic and pharmacodynamic characteristics of remifentanil with other opioids (fentanyl, sufentanil, alfentanil) are provided. Its unique properties (eg, organ function-independent metabolism, non-accumulation, rapid onset of action, and short duration of action) distinguish it from other opioid agents. Remifentanil is at least as effective as comparator opioids such as fentanyl, sufentanil in relieving pain and sedating patients during the perioperative period. In addition, it provides rapid and predictable extubation and is associated with shorter duration of mechanical ventilation and shorter length of hospitalization than comparators in some studies. In addition, remifentanil is well tolerated in both adults and children. Thus, remifentanil is a desirable addition to currently available pharmacologic agents used to treat period pain in patients https://perioperative.org.ua/index.php/prtmdc/article/view/116opioid analgesicsremifentanilgeneral anesthesia |
| spellingShingle | Dmytro Dmytriiev Oleksandr Nazarchuk Yuliana Babina Kateryna Dmytriieva Remifentanil: a review of its analgesic and sedative use in the perioperative period Perioperative Medicine opioid analgesics remifentanil general anesthesia |
| title | Remifentanil: a review of its analgesic and sedative use in the perioperative period |
| title_full | Remifentanil: a review of its analgesic and sedative use in the perioperative period |
| title_fullStr | Remifentanil: a review of its analgesic and sedative use in the perioperative period |
| title_full_unstemmed | Remifentanil: a review of its analgesic and sedative use in the perioperative period |
| title_short | Remifentanil: a review of its analgesic and sedative use in the perioperative period |
| title_sort | remifentanil a review of its analgesic and sedative use in the perioperative period |
| topic | opioid analgesics remifentanil general anesthesia |
| url | https://perioperative.org.ua/index.php/prtmdc/article/view/116 |
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