Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer
Abstract Background Circular RNAs (circRNAs) are a novel class of noncoding RNAs. Increasing evidence indicates that circRNAs play an important role in the occurrence and development of tumors. However, the role of circRNA hsa_circ_0044556 in the progression of colorectal cancer (CRC) remains unclea...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12935-020-01523-1 |
| _version_ | 1828422038230925312 |
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| author | Liang Jing Junhui Wu Xiaocheng Tang Min Ma Fei Long Buning Tian Changwei Lin |
| author_facet | Liang Jing Junhui Wu Xiaocheng Tang Min Ma Fei Long Buning Tian Changwei Lin |
| author_sort | Liang Jing |
| collection | DOAJ |
| description | Abstract Background Circular RNAs (circRNAs) are a novel class of noncoding RNAs. Increasing evidence indicates that circRNAs play an important role in the occurrence and development of tumors. However, the role of circRNA hsa_circ_0044556 in the progression of colorectal cancer (CRC) remains unclear. Methods First, we searched for differentially expressed circRNAs using a circRNA microarray in paired CRC and adjacent normal tissues. The circRNA hsa_circ_0044556 was screened out from the existing CRC circRNA microarray in the Gene Expression Omnibus database and our microarray. The clinical significance of hsa_circ_0044556 expression level in CRC patients was then investigated. Finally, the functions of the targets of this circRNA were determined in CRC cell lines. Results Hsa_circ_0044556 was highly expressed in CRC patients and was positively correlated with tumor stage and lymph node metastasis. In CRC cell lines, the proliferation, migration, and invasion of cancer cells were inhibited by knocking down hsa_circ_0044556 expression. Conclusion Hsa_circ_0044556 promoted the progression of CRC. It is possible that hsa_circ_0044556 will become a novel biomarker or therapeutic target for CRC. |
| first_indexed | 2024-12-10T15:42:01Z |
| format | Article |
| id | doaj.art-586e8f4ce8d14335abce16e5044a24d4 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-10T15:42:01Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-586e8f4ce8d14335abce16e5044a24d42022-12-22T01:43:05ZengBMCCancer Cell International1475-28672020-09-0120111310.1186/s12935-020-01523-1Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancerLiang Jing0Junhui Wu1Xiaocheng Tang2Min Ma3Fei Long4Buning Tian5Changwei Lin6Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South UniversityAbstract Background Circular RNAs (circRNAs) are a novel class of noncoding RNAs. Increasing evidence indicates that circRNAs play an important role in the occurrence and development of tumors. However, the role of circRNA hsa_circ_0044556 in the progression of colorectal cancer (CRC) remains unclear. Methods First, we searched for differentially expressed circRNAs using a circRNA microarray in paired CRC and adjacent normal tissues. The circRNA hsa_circ_0044556 was screened out from the existing CRC circRNA microarray in the Gene Expression Omnibus database and our microarray. The clinical significance of hsa_circ_0044556 expression level in CRC patients was then investigated. Finally, the functions of the targets of this circRNA were determined in CRC cell lines. Results Hsa_circ_0044556 was highly expressed in CRC patients and was positively correlated with tumor stage and lymph node metastasis. In CRC cell lines, the proliferation, migration, and invasion of cancer cells were inhibited by knocking down hsa_circ_0044556 expression. Conclusion Hsa_circ_0044556 promoted the progression of CRC. It is possible that hsa_circ_0044556 will become a novel biomarker or therapeutic target for CRC.http://link.springer.com/article/10.1186/s12935-020-01523-1Noncoding RNACircular RNAColorectal cancerhsa_circ_0044556Biomarker |
| spellingShingle | Liang Jing Junhui Wu Xiaocheng Tang Min Ma Fei Long Buning Tian Changwei Lin Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer Cancer Cell International Noncoding RNA Circular RNA Colorectal cancer hsa_circ_0044556 Biomarker |
| title | Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer |
| title_full | Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer |
| title_fullStr | Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer |
| title_full_unstemmed | Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer |
| title_short | Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer |
| title_sort | identification of circular rna hsa circ 0044556 and its effect on the progression of colorectal cancer |
| topic | Noncoding RNA Circular RNA Colorectal cancer hsa_circ_0044556 Biomarker |
| url | http://link.springer.com/article/10.1186/s12935-020-01523-1 |
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