Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy
BackgroundApathy is one of the most common non-motor symptoms of Parkinson’s disease (PD). However, its pathophysiology remains unclear.MethodsWe analyzed resting-state functional magnetic resonance imaging (MRI) data acquired at a 3.0T MRI scanner using the amplitude of low-frequency fluctuation (A...
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00830/full |
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| author | Hai-Hua Sun Jian-Bin Hu Jing Chen Xue-Yang Wang Xiao-Li Wang Ping-Lei Pan Chun-Feng Liu Chun-Feng Liu |
| author_facet | Hai-Hua Sun Jian-Bin Hu Jing Chen Xue-Yang Wang Xiao-Li Wang Ping-Lei Pan Chun-Feng Liu Chun-Feng Liu |
| author_sort | Hai-Hua Sun |
| collection | DOAJ |
| description | BackgroundApathy is one of the most common non-motor symptoms of Parkinson’s disease (PD). However, its pathophysiology remains unclear.MethodsWe analyzed resting-state functional magnetic resonance imaging (MRI) data acquired at a 3.0T MRI scanner using the amplitude of low-frequency fluctuation (ALFF) metric in 20 de novo, drug-naïve, non-demented PD patients with apathy (PD-A), 26 PD patients without apathy (PD-NA) without comorbidity of depressive or anxious symptoms, and 23 matched healthy control (HC) subjects.ResultsWe found that the ALFF decreased significantly in the bilateral nucleus accumbens, dorsal anterior cingulate cortex (ACC), and left dorsolateral prefrontal cortex in patients with PD-A compared to patients with PD-NA and HC subjects. Furthermore, apathy severity was negatively correlated with the ALFF in the bilateral nucleus accumbens and dorsal ACC in the pooled patients with PD.ConclusionThe present study characterized the functional pattern of changes in spontaneous neural activity in patients with PD-A. With the aim to better elucidate the pathophysiological mechanisms responsible for these changes, this study controlled for the potentially confounding effects of dopaminergic medication, depression, anxiety, and global cognitive impairment. The findings of the current study add to the literature by highlighting potential abnormalities in mesocorticolimbic pathways involved in the development of apathy in PD. |
| first_indexed | 2024-12-14T03:48:15Z |
| format | Article |
| id | doaj.art-586ecd9d33084a65aab8cd24c6b75803 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-14T03:48:15Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-586ecd9d33084a65aab8cd24c6b758032022-12-21T23:18:18ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-08-011410.3389/fnins.2020.00830544688Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” ApathyHai-Hua Sun0Jian-Bin Hu1Jing Chen2Xue-Yang Wang3Xiao-Li Wang4Ping-Lei Pan5Chun-Feng Liu6Chun-Feng Liu7Department of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, ChinaDepartment of Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, ChinaDepartment of Emergency, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, ChinaDepartment of Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience, Soochow University, Suzhou, ChinaBackgroundApathy is one of the most common non-motor symptoms of Parkinson’s disease (PD). However, its pathophysiology remains unclear.MethodsWe analyzed resting-state functional magnetic resonance imaging (MRI) data acquired at a 3.0T MRI scanner using the amplitude of low-frequency fluctuation (ALFF) metric in 20 de novo, drug-naïve, non-demented PD patients with apathy (PD-A), 26 PD patients without apathy (PD-NA) without comorbidity of depressive or anxious symptoms, and 23 matched healthy control (HC) subjects.ResultsWe found that the ALFF decreased significantly in the bilateral nucleus accumbens, dorsal anterior cingulate cortex (ACC), and left dorsolateral prefrontal cortex in patients with PD-A compared to patients with PD-NA and HC subjects. Furthermore, apathy severity was negatively correlated with the ALFF in the bilateral nucleus accumbens and dorsal ACC in the pooled patients with PD.ConclusionThe present study characterized the functional pattern of changes in spontaneous neural activity in patients with PD-A. With the aim to better elucidate the pathophysiological mechanisms responsible for these changes, this study controlled for the potentially confounding effects of dopaminergic medication, depression, anxiety, and global cognitive impairment. The findings of the current study add to the literature by highlighting potential abnormalities in mesocorticolimbic pathways involved in the development of apathy in PD.https://www.frontiersin.org/article/10.3389/fnins.2020.00830/fullapathyParkinson’s diseaseamplitude of low-frequency fluctuationnucleus accumbensdorsal anterior cingulate cortex |
| spellingShingle | Hai-Hua Sun Jian-Bin Hu Jing Chen Xue-Yang Wang Xiao-Li Wang Ping-Lei Pan Chun-Feng Liu Chun-Feng Liu Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy Frontiers in Neuroscience apathy Parkinson’s disease amplitude of low-frequency fluctuation nucleus accumbens dorsal anterior cingulate cortex |
| title | Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy |
| title_full | Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy |
| title_fullStr | Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy |
| title_full_unstemmed | Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy |
| title_short | Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy |
| title_sort | abnormal spontaneous neural activity in parkinson s disease with pure apathy |
| topic | apathy Parkinson’s disease amplitude of low-frequency fluctuation nucleus accumbens dorsal anterior cingulate cortex |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00830/full |
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