Antimicrobial Activity of Lactones
The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/10/1327 |
| _version_ | 1827652149049294848 |
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| author | Marcelina Mazur Dorota Masłowiec |
| author_facet | Marcelina Mazur Dorota Masłowiec |
| author_sort | Marcelina Mazur |
| collection | DOAJ |
| description | The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimicrobial potential, lactones are a group to explore. For centuries, their antimicrobial activities have been used in folk medicine. Currently, novel lactone compounds are continuously described in the literature. Some of those structures exhibit high antimicrobial potential and some are an inspiration for design and synthesis of future drugs. This paper describes recent developments on antimicrobial lactones with smaller ring sizes, up to seven membered ε-lactones. Their isolation from natural sources, chemical synthesis, synergistic activity with antibiotics, and effects on quorum sensing are presented herein. |
| first_indexed | 2024-03-09T20:50:35Z |
| format | Article |
| id | doaj.art-586fa815f7984f6b80685476ac1c3507 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T20:50:35Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-586fa815f7984f6b80685476ac1c35072023-11-23T22:34:36ZengMDPI AGAntibiotics2079-63822022-09-011110132710.3390/antibiotics11101327Antimicrobial Activity of LactonesMarcelina Mazur0Dorota Masłowiec1Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, PolandInstitute of Health Sciences, University of Opole, Katowicka 68, 45-060 Opole, PolandThe development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimicrobial potential, lactones are a group to explore. For centuries, their antimicrobial activities have been used in folk medicine. Currently, novel lactone compounds are continuously described in the literature. Some of those structures exhibit high antimicrobial potential and some are an inspiration for design and synthesis of future drugs. This paper describes recent developments on antimicrobial lactones with smaller ring sizes, up to seven membered ε-lactones. Their isolation from natural sources, chemical synthesis, synergistic activity with antibiotics, and effects on quorum sensing are presented herein.https://www.mdpi.com/2079-6382/11/10/1327lactonesantimicrobial compoundsantibacterial activityisolation of lactonesquorum sensing |
| spellingShingle | Marcelina Mazur Dorota Masłowiec Antimicrobial Activity of Lactones Antibiotics lactones antimicrobial compounds antibacterial activity isolation of lactones quorum sensing |
| title | Antimicrobial Activity of Lactones |
| title_full | Antimicrobial Activity of Lactones |
| title_fullStr | Antimicrobial Activity of Lactones |
| title_full_unstemmed | Antimicrobial Activity of Lactones |
| title_short | Antimicrobial Activity of Lactones |
| title_sort | antimicrobial activity of lactones |
| topic | lactones antimicrobial compounds antibacterial activity isolation of lactones quorum sensing |
| url | https://www.mdpi.com/2079-6382/11/10/1327 |
| work_keys_str_mv | AT marcelinamazur antimicrobialactivityoflactones AT dorotamasłowiec antimicrobialactivityoflactones |