The Effect of Antenatal L-Arginine and Antioxidant Supplementation on Oxidative Stress Marker Levels in Newborns
Introduction:The present study was conducted in the Department of Obstetrics, Paediatrics & Biophysics IMS, BHU, Varanasi with an aim to study the role of L-arginine and oral antioxidants as a part of therapy in patients diagnosed with IUGR (Intra uterine growth restriction ) and cord serum...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4966/8343_CE(Ra)_F(Sh)_PF1(PAK)_PFA(Sh)_PF2(PAG).pdf |
| Summary: | Introduction:The present study was conducted in the Department
of Obstetrics, Paediatrics & Biophysics IMS, BHU, Varanasi with
an aim to study the role of L-arginine and oral antioxidants
as a part of therapy in patients diagnosed with IUGR (Intra
uterine growth restriction ) and cord serum NO and oxidative
stress markers GSH and SOD in newborns following delivery
of such patients.
Materials and Methods: The study included 40 pregnant
patient between 30-32 weeks of gestation diagnosed with
IUGR who were divided into 3 groups: Group I (treated with
L-arginine N=10), Group II (treated with antioxidants N=10),
Group III (without nutritional supplementation N=10) and Group
IV (healthy control pregnant patients of same gestational age
range N=10) were taken. Cord serum NO & oxidative stress
markers (GSH & SOD) were measured following delivery of
patients from those four groups.
Results: The cord serum NO levels (µmol/lt) showed a
significant increase & SOD (U/ml) & GSH (U/lt) values were
increased in newborns to mothers diagnosed with IUGR after
treatment with L-arginine. Similar results were obtained for
treatment with antioxidants.
Conclusion: The reduced NO & reduced cord serum circulating
levels of oxidative stress markers (GSH & SOD) activity may
play an important role in the occurrence of IUGR. |
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| ISSN: | 2249-782X 0973-709X |