The experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practice
Objective: to study the antihypertensive efficacy of a new dosage form of perindopril A — tablets dispersed in the oral cavity — in the group of patients with arterial hypertension (AH) on an outpatient basis.Material and methods: the study included 30 patients (mean age 53.8 ± 0.9 years) with the p...
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| Format: | Article |
| Language: | English |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2019-10-01
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| Series: | Медицинский вестник Юга России |
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| Online Access: | https://www.medicalherald.ru/jour/article/view/852 |
| _version_ | 1811179383437656064 |
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| author | S. A. Solgalova T. V. Glukhova I. A. Znamenskaya I. B. Romanova |
| author_facet | S. A. Solgalova T. V. Glukhova I. A. Znamenskaya I. B. Romanova |
| author_sort | S. A. Solgalova |
| collection | DOAJ |
| description | Objective: to study the antihypertensive efficacy of a new dosage form of perindopril A — tablets dispersed in the oral cavity — in the group of patients with arterial hypertension (AH) on an outpatient basis.Material and methods: the study included 30 patients (mean age 53.8 ± 0.9 years) with the presence of arterial hypertension, diagnosed initially, or with no control of blood pressure at the background of previous antihypertensive therapy. All investigators were administered perindopril A in the form of a dispersible form in a dose of 10 mg in monotherapy or in combination with indapamide – in case of failure to achieve target blood pressure after 2 weeks of observation. The total duration of the study is 3 months.Results: by the end of the observation, the SBP / DBP decreased by 35.6 ± 2.3 / 16.5 ± 1.0 mm Hg. Correction of therapy with the addition of indapamide-retard was required in 6 (20%) patients. Effective antihypertensive therapy was accompanied by a significant decrease in daily (according to ICBP data), intravisit, and visit-to-visit variability of the SBP, which was 4.4 mm Hg in terms of standard deviation by the end of the observation. The use of a new dosage form of perindopril A was accompanied by a significant increase in adherence to therapy.Conclusion: the use of a new dosage form of perindopril A — tablets dispersed in the oral cavity — in monotherapy or in combination with indapamide-retard can improve the treatment of patients with hypertension who do not have target BP values. |
| first_indexed | 2024-04-11T06:34:46Z |
| format | Article |
| id | doaj.art-5872588ffdf242029baac14e027b9c9a |
| institution | Directory Open Access Journal |
| issn | 2219-8075 2618-7876 |
| language | English |
| last_indexed | 2024-04-11T06:34:46Z |
| publishDate | 2019-10-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj.art-5872588ffdf242029baac14e027b9c9a2022-12-22T04:39:52ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762019-10-01103627110.21886/2219-8075-2019-10-3-62-71511The experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practiceS. A. Solgalova0T. V. Glukhova1I. A. Znamenskaya2I. B. Romanova3Stavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical UniversityObjective: to study the antihypertensive efficacy of a new dosage form of perindopril A — tablets dispersed in the oral cavity — in the group of patients with arterial hypertension (AH) on an outpatient basis.Material and methods: the study included 30 patients (mean age 53.8 ± 0.9 years) with the presence of arterial hypertension, diagnosed initially, or with no control of blood pressure at the background of previous antihypertensive therapy. All investigators were administered perindopril A in the form of a dispersible form in a dose of 10 mg in monotherapy or in combination with indapamide – in case of failure to achieve target blood pressure after 2 weeks of observation. The total duration of the study is 3 months.Results: by the end of the observation, the SBP / DBP decreased by 35.6 ± 2.3 / 16.5 ± 1.0 mm Hg. Correction of therapy with the addition of indapamide-retard was required in 6 (20%) patients. Effective antihypertensive therapy was accompanied by a significant decrease in daily (according to ICBP data), intravisit, and visit-to-visit variability of the SBP, which was 4.4 mm Hg in terms of standard deviation by the end of the observation. The use of a new dosage form of perindopril A was accompanied by a significant increase in adherence to therapy.Conclusion: the use of a new dosage form of perindopril A — tablets dispersed in the oral cavity — in monotherapy or in combination with indapamide-retard can improve the treatment of patients with hypertension who do not have target BP values.https://www.medicalherald.ru/jour/article/view/852arterial hypertensionvariability of blood pressureadherence to therapy |
| spellingShingle | S. A. Solgalova T. V. Glukhova I. A. Znamenskaya I. B. Romanova The experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practice Медицинский вестник Юга России arterial hypertension variability of blood pressure adherence to therapy |
| title | The experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practice |
| title_full | The experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practice |
| title_fullStr | The experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practice |
| title_full_unstemmed | The experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practice |
| title_short | The experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practice |
| title_sort | experience of a comprehensive assessment of the effectiveness of antihypertensive therapy in clinical practice |
| topic | arterial hypertension variability of blood pressure adherence to therapy |
| url | https://www.medicalherald.ru/jour/article/view/852 |
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