Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies
A large number of studies link H. pylori infection with a reduced risk of developing extra-gastric conditions such as allergy, asthma, inflammatory bowel disease, coeliac disease and multiple sclerosis. The strength of the evidence for these protective associations is quite variable, and published s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-03-01
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| Series: | Diseases |
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| Online Access: | http://www.mdpi.com/2079-9721/3/2/34 |
| _version_ | 1818498638337277952 |
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| author | Karen Robinson |
| author_facet | Karen Robinson |
| author_sort | Karen Robinson |
| collection | DOAJ |
| description | A large number of studies link H. pylori infection with a reduced risk of developing extra-gastric conditions such as allergy, asthma, inflammatory bowel disease, coeliac disease and multiple sclerosis. The strength of the evidence for these protective associations is quite variable, and published studies often do not agree. This review article discusses some of the reasons for these discrepancies, and the difficulties faced when designing studies. Examples of some protective disease associations are described in detail, where the evidence is most abundant and thought to be more reliable. The most convincing of these are supported by published mechanistic data, for example with animal models, or incidence of disease exacerbation in humans following H. pylori eradication. Although controversial, this field is very important as the prevalence of H. pylori is decreasing throughout the world whilst many chronic diseases are becoming more common. These trends are likely to continue in the future, therefore it is important that we fully understand if and how H. pylori confers protection. |
| first_indexed | 2024-12-10T20:18:18Z |
| format | Article |
| id | doaj.art-5872614a79c341ee992b7a14c5a63bc2 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-12-10T20:18:18Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-5872614a79c341ee992b7a14c5a63bc22022-12-22T01:35:07ZengMDPI AGDiseases2079-97212015-03-0132345510.3390/diseases3020034diseases3020034Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and ControversiesKaren Robinson0Nottingham Digestive Diseases Biomedical Research Unit, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UKA large number of studies link H. pylori infection with a reduced risk of developing extra-gastric conditions such as allergy, asthma, inflammatory bowel disease, coeliac disease and multiple sclerosis. The strength of the evidence for these protective associations is quite variable, and published studies often do not agree. This review article discusses some of the reasons for these discrepancies, and the difficulties faced when designing studies. Examples of some protective disease associations are described in detail, where the evidence is most abundant and thought to be more reliable. The most convincing of these are supported by published mechanistic data, for example with animal models, or incidence of disease exacerbation in humans following H. pylori eradication. Although controversial, this field is very important as the prevalence of H. pylori is decreasing throughout the world whilst many chronic diseases are becoming more common. These trends are likely to continue in the future, therefore it is important that we fully understand if and how H. pylori confers protection.http://www.mdpi.com/2079-9721/3/2/34Helicobacter pyloriextra-gastric manifestationsGORDasthmaallergyautoimmuity |
| spellingShingle | Karen Robinson Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies Diseases Helicobacter pylori extra-gastric manifestations GORD asthma allergy autoimmuity |
| title | Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies |
| title_full | Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies |
| title_fullStr | Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies |
| title_full_unstemmed | Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies |
| title_short | Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies |
| title_sort | helicobacter pylori mediated protection against extra gastric immune and inflammatory disorders the evidence and controversies |
| topic | Helicobacter pylori extra-gastric manifestations GORD asthma allergy autoimmuity |
| url | http://www.mdpi.com/2079-9721/3/2/34 |
| work_keys_str_mv | AT karenrobinson helicobacterpylorimediatedprotectionagainstextragastricimmuneandinflammatorydisorderstheevidenceandcontroversies |