Pre-Existing HSV-1 Immunity Enhances Anticancer Efficacy of a Novel Immune-Stimulating Oncolytic Virus

Pre-Existing HSV-1 Immunity Enhances Anticancer Efficacy of a Novel Immune-Stimulating Oncolytic Virus

Oncolytic viruses (OVs) can specifically replicate in the host and cause cancer cell lysis while inducing an antitumor immune response. The aim of this study is to investigate the impact of either pre-existing immunity against herpes simplex virus type-1 (HSV-1) or multicycle treatment with OVs on a...

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Bibliographic Details
Main Authors: Jun Ding, Yanal M. Murad, Yi Sun, I-Fang Lee, Ismael Samudio, Xiaohu Liu, William Wei-Guo Jia, Ronghua Zhao
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
oncolytic viruses
immunotherapy
HSV-1
Online Access:https://www.mdpi.com/1999-4915/14/11/2327

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