Smart Supra- and Macro-Molecular Tools for Biomedical Applications
Stimuli-responsive, “smart” polymeric materials used in the biomedical field function in a bio-mimicking manner by providing a non-linear response to triggers coming from a physiological microenvironment or other external source. They are built based on various chemical, physical, and biological too...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/13/15/3343 |
| _version_ | 1797561140318830592 |
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| author | Mariana Pinteala Marc J. M. Abadie Radu D. Rusu |
| author_facet | Mariana Pinteala Marc J. M. Abadie Radu D. Rusu |
| author_sort | Mariana Pinteala |
| collection | DOAJ |
| description | Stimuli-responsive, “smart” polymeric materials used in the biomedical field function in a bio-mimicking manner by providing a non-linear response to triggers coming from a physiological microenvironment or other external source. They are built based on various chemical, physical, and biological tools that enable pH and/or temperature-stimulated changes in structural or physicochemical attributes, like shape, volume, solubility, supramolecular arrangement, and others. This review touches on some particular developments on the topic of stimuli-sensitive molecular tools for biomedical applications. Design and mechanistic details are provided concerning the smart synthetic instruments that are employed to prepare supra- and macro-molecular architectures with specific responses to external stimuli. Five major themes are approached: (i) temperature- and pH-responsive systems for controlled drug delivery; (ii) glycodynameric hydrogels for drug delivery; (iii) polymeric non-viral vectors for gene delivery; (iv) metallic nanoconjugates for biomedical applications; and, (v) smart organic tools for biomedical imaging. |
| first_indexed | 2024-03-10T18:10:01Z |
| format | Article |
| id | doaj.art-5872970ea16e41f4a17d1d07dcb3c218 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T18:10:01Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-5872970ea16e41f4a17d1d07dcb3c2182023-11-20T08:08:52ZengMDPI AGMaterials1996-19442020-07-011315334310.3390/ma13153343Smart Supra- and Macro-Molecular Tools for Biomedical ApplicationsMariana Pinteala0Marc J. M. Abadie1Radu D. Rusu2“Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley, 41A, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley, 41A, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley, 41A, 700487 Iasi, RomaniaStimuli-responsive, “smart” polymeric materials used in the biomedical field function in a bio-mimicking manner by providing a non-linear response to triggers coming from a physiological microenvironment or other external source. They are built based on various chemical, physical, and biological tools that enable pH and/or temperature-stimulated changes in structural or physicochemical attributes, like shape, volume, solubility, supramolecular arrangement, and others. This review touches on some particular developments on the topic of stimuli-sensitive molecular tools for biomedical applications. Design and mechanistic details are provided concerning the smart synthetic instruments that are employed to prepare supra- and macro-molecular architectures with specific responses to external stimuli. Five major themes are approached: (i) temperature- and pH-responsive systems for controlled drug delivery; (ii) glycodynameric hydrogels for drug delivery; (iii) polymeric non-viral vectors for gene delivery; (iv) metallic nanoconjugates for biomedical applications; and, (v) smart organic tools for biomedical imaging.https://www.mdpi.com/1996-1944/13/15/3343smart polymerstemperature-sensitive polymerspH-responsive polymershydrogelscontrolled drug deliverygene therapy |
| spellingShingle | Mariana Pinteala Marc J. M. Abadie Radu D. Rusu Smart Supra- and Macro-Molecular Tools for Biomedical Applications Materials smart polymers temperature-sensitive polymers pH-responsive polymers hydrogels controlled drug delivery gene therapy |
| title | Smart Supra- and Macro-Molecular Tools for Biomedical Applications |
| title_full | Smart Supra- and Macro-Molecular Tools for Biomedical Applications |
| title_fullStr | Smart Supra- and Macro-Molecular Tools for Biomedical Applications |
| title_full_unstemmed | Smart Supra- and Macro-Molecular Tools for Biomedical Applications |
| title_short | Smart Supra- and Macro-Molecular Tools for Biomedical Applications |
| title_sort | smart supra and macro molecular tools for biomedical applications |
| topic | smart polymers temperature-sensitive polymers pH-responsive polymers hydrogels controlled drug delivery gene therapy |
| url | https://www.mdpi.com/1996-1944/13/15/3343 |
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