Annotation matters: validating the discovery of cancer drivers
Advanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analysis of gene and protein annotation are essential to verify such discoveries. Our recent study of STK19 (Serine Threonine Kinase 19), a previously identified melanoma d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1806679 |
| _version_ | 1797677076122173440 |
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| author | Marta Rodríguez-Martínez Jesper Q. Svejstrup |
| author_facet | Marta Rodríguez-Martínez Jesper Q. Svejstrup |
| author_sort | Marta Rodríguez-Martínez |
| collection | DOAJ |
| description | Advanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analysis of gene and protein annotation are essential to verify such discoveries. Our recent study of STK19 (Serine Threonine Kinase 19), a previously identified melanoma driver, is a clear example of the importance of such detailed analysis, with both STK19 gene and protein annotations in frequently used databases having been proven incorrect. |
| first_indexed | 2024-03-11T22:39:48Z |
| format | Article |
| id | doaj.art-5875710c5aa34738909100f3eeb0c263 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:48Z |
| publishDate | 2020-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-5875710c5aa34738909100f3eeb0c2632023-09-22T09:11:02ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-11-017610.1080/23723556.2020.18066791806679Annotation matters: validating the discovery of cancer driversMarta Rodríguez-Martínez0Jesper Q. Svejstrup1The Francis Crick InstituteThe Francis Crick InstituteAdvanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analysis of gene and protein annotation are essential to verify such discoveries. Our recent study of STK19 (Serine Threonine Kinase 19), a previously identified melanoma driver, is a clear example of the importance of such detailed analysis, with both STK19 gene and protein annotations in frequently used databases having been proven incorrect.http://dx.doi.org/10.1080/23723556.2020.1806679stk19annotationcancer driverkinase |
| spellingShingle | Marta Rodríguez-Martínez Jesper Q. Svejstrup Annotation matters: validating the discovery of cancer drivers Molecular & Cellular Oncology stk19 annotation cancer driver kinase |
| title | Annotation matters: validating the discovery of cancer drivers |
| title_full | Annotation matters: validating the discovery of cancer drivers |
| title_fullStr | Annotation matters: validating the discovery of cancer drivers |
| title_full_unstemmed | Annotation matters: validating the discovery of cancer drivers |
| title_short | Annotation matters: validating the discovery of cancer drivers |
| title_sort | annotation matters validating the discovery of cancer drivers |
| topic | stk19 annotation cancer driver kinase |
| url | http://dx.doi.org/10.1080/23723556.2020.1806679 |
| work_keys_str_mv | AT martarodriguezmartinez annotationmattersvalidatingthediscoveryofcancerdrivers AT jesperqsvejstrup annotationmattersvalidatingthediscoveryofcancerdrivers |