New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma
The ultra-functional potential of nickel oxide (NiO) and magnesium oxide (MgO) nanoparticles (NPs), provides for extensive attention in the use of these metal oxides as a remarkable and electroactive nanocomposite in potentiometric and sensing investigations. This work proposed a new strategy for qu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/12/12/3066 |
| Summary: | The ultra-functional potential of nickel oxide (NiO) and magnesium oxide (MgO) nanoparticles (NPs), provides for extensive attention in the use of these metal oxides as a remarkable and electroactive nanocomposite in potentiometric and sensing investigations. This work proposed a new strategy for quantifying doxorubicin hydrochloride (DOX) in pharmaceuticals and human plasma by preparing a NiO/MgO core-shell nanocomposite modified coated wire membrane sensor. Doxorubicin hydrochloride was incorporated with phosphomolybdic acid (PMA) to produce doxorubicin hydrochloride phosphomolybdate (DOX-PM) as an electroactive material in the presence of polymeric high molecular weight poly vinyl chloride (PVC) and solvent mediator <i>o</i>-nitrophenyloctyl ether (<i>o</i>-NPOE). The modified sensor exhibited ultra sensitivity and high selectivity for the detection and quantification of doxorubicin hydrochloride with a linear relationship in the range of 1.0 × 10<sup>−11</sup>–1.0 × 10<sup>−2</sup> mol L<sup>−1</sup>. The equation of regression was estimated to be E<sub>mV</sub> = (57.86 ± 0.8) log [DOX] + 723.19. However, the conventional type DOX-PM showed a potential response over a concentration range of 1.0 × 10<sup>−6</sup>–1.0 × 10<sup>−2</sup> mol L<sup>−1</sup> and a regression equation of E<sub>mV</sub> = (52.92 ± 0.5) log [DOX] + 453.42. The suggested sensors were successfully used in the determination of doxorubicin hydrochloride in commercial injections and human plasma. |
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| ISSN: | 2073-4360 |