New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma
The ultra-functional potential of nickel oxide (NiO) and magnesium oxide (MgO) nanoparticles (NPs), provides for extensive attention in the use of these metal oxides as a remarkable and electroactive nanocomposite in potentiometric and sensing investigations. This work proposed a new strategy for qu...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/12/3066 |
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| author | Nawal A. Alarfaj Maha F. El-Tohamy |
| author_facet | Nawal A. Alarfaj Maha F. El-Tohamy |
| author_sort | Nawal A. Alarfaj |
| collection | DOAJ |
| description | The ultra-functional potential of nickel oxide (NiO) and magnesium oxide (MgO) nanoparticles (NPs), provides for extensive attention in the use of these metal oxides as a remarkable and electroactive nanocomposite in potentiometric and sensing investigations. This work proposed a new strategy for quantifying doxorubicin hydrochloride (DOX) in pharmaceuticals and human plasma by preparing a NiO/MgO core-shell nanocomposite modified coated wire membrane sensor. Doxorubicin hydrochloride was incorporated with phosphomolybdic acid (PMA) to produce doxorubicin hydrochloride phosphomolybdate (DOX-PM) as an electroactive material in the presence of polymeric high molecular weight poly vinyl chloride (PVC) and solvent mediator <i>o</i>-nitrophenyloctyl ether (<i>o</i>-NPOE). The modified sensor exhibited ultra sensitivity and high selectivity for the detection and quantification of doxorubicin hydrochloride with a linear relationship in the range of 1.0 × 10<sup>−11</sup>–1.0 × 10<sup>−2</sup> mol L<sup>−1</sup>. The equation of regression was estimated to be E<sub>mV</sub> = (57.86 ± 0.8) log [DOX] + 723.19. However, the conventional type DOX-PM showed a potential response over a concentration range of 1.0 × 10<sup>−6</sup>–1.0 × 10<sup>−2</sup> mol L<sup>−1</sup> and a regression equation of E<sub>mV</sub> = (52.92 ± 0.5) log [DOX] + 453.42. The suggested sensors were successfully used in the determination of doxorubicin hydrochloride in commercial injections and human plasma. |
| first_indexed | 2024-03-10T13:53:25Z |
| format | Article |
| id | doaj.art-5877205e6f9e4300b5f73faf2c8d08ab |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T13:53:25Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-5877205e6f9e4300b5f73faf2c8d08ab2023-11-21T01:54:13ZengMDPI AGPolymers2073-43602020-12-011212306610.3390/polym12123066New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human PlasmaNawal A. Alarfaj0Maha F. El-Tohamy1Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi ArabiaThe ultra-functional potential of nickel oxide (NiO) and magnesium oxide (MgO) nanoparticles (NPs), provides for extensive attention in the use of these metal oxides as a remarkable and electroactive nanocomposite in potentiometric and sensing investigations. This work proposed a new strategy for quantifying doxorubicin hydrochloride (DOX) in pharmaceuticals and human plasma by preparing a NiO/MgO core-shell nanocomposite modified coated wire membrane sensor. Doxorubicin hydrochloride was incorporated with phosphomolybdic acid (PMA) to produce doxorubicin hydrochloride phosphomolybdate (DOX-PM) as an electroactive material in the presence of polymeric high molecular weight poly vinyl chloride (PVC) and solvent mediator <i>o</i>-nitrophenyloctyl ether (<i>o</i>-NPOE). The modified sensor exhibited ultra sensitivity and high selectivity for the detection and quantification of doxorubicin hydrochloride with a linear relationship in the range of 1.0 × 10<sup>−11</sup>–1.0 × 10<sup>−2</sup> mol L<sup>−1</sup>. The equation of regression was estimated to be E<sub>mV</sub> = (57.86 ± 0.8) log [DOX] + 723.19. However, the conventional type DOX-PM showed a potential response over a concentration range of 1.0 × 10<sup>−6</sup>–1.0 × 10<sup>−2</sup> mol L<sup>−1</sup> and a regression equation of E<sub>mV</sub> = (52.92 ± 0.5) log [DOX] + 453.42. The suggested sensors were successfully used in the determination of doxorubicin hydrochloride in commercial injections and human plasma.https://www.mdpi.com/2073-4360/12/12/3066doxorubicin hydrochloridemodified sensorsmetal oxide nanocompositeshuman plasmacommercial injections |
| spellingShingle | Nawal A. Alarfaj Maha F. El-Tohamy New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma Polymers doxorubicin hydrochloride modified sensors metal oxide nanocomposites human plasma commercial injections |
| title | New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma |
| title_full | New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma |
| title_fullStr | New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma |
| title_full_unstemmed | New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma |
| title_short | New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma |
| title_sort | new functionalized polymeric sensor based nio mgo nanocomposite for potentiometric determination of doxorubicin hydrochloride in commercial injections and human plasma |
| topic | doxorubicin hydrochloride modified sensors metal oxide nanocomposites human plasma commercial injections |
| url | https://www.mdpi.com/2073-4360/12/12/3066 |
| work_keys_str_mv | AT nawalaalarfaj newfunctionalizedpolymericsensorbasedniomgonanocompositeforpotentiometricdeterminationofdoxorubicinhydrochlorideincommercialinjectionsandhumanplasma AT mahafeltohamy newfunctionalizedpolymericsensorbasedniomgonanocompositeforpotentiometricdeterminationofdoxorubicinhydrochlorideincommercialinjectionsandhumanplasma |