Electrospun Bioscaffold Based on Cellulose Acetate and Dendrimer-modified Cellulose Nanocrystals for Controlled Drug Release
Side effects of high concentration of drug, related to high initial burst release still are major challenges of pharmacotherapy. This field demands novel drug release control methods. In this research, cellulose nanocrystals were modified via physical adsorption of polyamidoamine and used as an addi...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893922000056 |
| _version_ | 1811243450723467264 |
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| author | Ali Mianehro |
| author_facet | Ali Mianehro |
| author_sort | Ali Mianehro |
| collection | DOAJ |
| description | Side effects of high concentration of drug, related to high initial burst release still are major challenges of pharmacotherapy. This field demands novel drug release control methods. In this research, cellulose nanocrystals were modified via physical adsorption of polyamidoamine and used as an additive into electrospun cellulose acetate matrix. Characterizations confirmed successful modification of CNC, intactness of crystallinity, and perfect antibacterial activity. Zeta potential of the nanoparticles shifted from -12 eV to +23 eV. The modified CNC demonstrated 17800 cm−1 Stocks shift. The addition of modified CNC to cellulose acetate reduced the nanofiber diameter up to 75% and improved mechanical properties. Electrospun cellulose acetate containing modified CNC perfectly controlled the release rate of tranexamic acid and improved the ultimate release amount of the gatifloxacin. The results of this work pave the way for preparing safe clinically applicable antibacterial bioscaffolds with controlled drug release, without needing any toxic reagent and chemical reaction. |
| first_indexed | 2024-04-12T14:07:31Z |
| format | Article |
| id | doaj.art-58796e618dce4bdfa86044f9a5bc9e12 |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-04-12T14:07:31Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-58796e618dce4bdfa86044f9a5bc9e122022-12-22T03:30:01ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392022-06-013100187Electrospun Bioscaffold Based on Cellulose Acetate and Dendrimer-modified Cellulose Nanocrystals for Controlled Drug ReleaseAli Mianehro0Corresponding author: 424 Hafez Ave, Tehran, Iran, 15875-4413. Tel: +989128455104; Fax: +98 2166400245.; Department of Textile Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, 15875-4413, IranSide effects of high concentration of drug, related to high initial burst release still are major challenges of pharmacotherapy. This field demands novel drug release control methods. In this research, cellulose nanocrystals were modified via physical adsorption of polyamidoamine and used as an additive into electrospun cellulose acetate matrix. Characterizations confirmed successful modification of CNC, intactness of crystallinity, and perfect antibacterial activity. Zeta potential of the nanoparticles shifted from -12 eV to +23 eV. The modified CNC demonstrated 17800 cm−1 Stocks shift. The addition of modified CNC to cellulose acetate reduced the nanofiber diameter up to 75% and improved mechanical properties. Electrospun cellulose acetate containing modified CNC perfectly controlled the release rate of tranexamic acid and improved the ultimate release amount of the gatifloxacin. The results of this work pave the way for preparing safe clinically applicable antibacterial bioscaffolds with controlled drug release, without needing any toxic reagent and chemical reaction.http://www.sciencedirect.com/science/article/pii/S2666893922000056Cellulose nanocrystalPolyamidoamideElectrospinningSurface modificationScaffoldcontrolled release |
| spellingShingle | Ali Mianehro Electrospun Bioscaffold Based on Cellulose Acetate and Dendrimer-modified Cellulose Nanocrystals for Controlled Drug Release Carbohydrate Polymer Technologies and Applications Cellulose nanocrystal Polyamidoamide Electrospinning Surface modification Scaffold controlled release |
| title | Electrospun Bioscaffold Based on Cellulose Acetate and Dendrimer-modified Cellulose Nanocrystals for Controlled Drug Release |
| title_full | Electrospun Bioscaffold Based on Cellulose Acetate and Dendrimer-modified Cellulose Nanocrystals for Controlled Drug Release |
| title_fullStr | Electrospun Bioscaffold Based on Cellulose Acetate and Dendrimer-modified Cellulose Nanocrystals for Controlled Drug Release |
| title_full_unstemmed | Electrospun Bioscaffold Based on Cellulose Acetate and Dendrimer-modified Cellulose Nanocrystals for Controlled Drug Release |
| title_short | Electrospun Bioscaffold Based on Cellulose Acetate and Dendrimer-modified Cellulose Nanocrystals for Controlled Drug Release |
| title_sort | electrospun bioscaffold based on cellulose acetate and dendrimer modified cellulose nanocrystals for controlled drug release |
| topic | Cellulose nanocrystal Polyamidoamide Electrospinning Surface modification Scaffold controlled release |
| url | http://www.sciencedirect.com/science/article/pii/S2666893922000056 |
| work_keys_str_mv | AT alimianehro electrospunbioscaffoldbasedoncelluloseacetateanddendrimermodifiedcellulosenanocrystalsforcontrolleddrugrelease |