Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management
Diabetes, particularly type 2 diabetes (T2D), is the main component of metabolic syndrome. It is highly prevalent and has drastically increased with sedentary lifestyles, notably behaviors linked to ease of access and minimal physical activity. Central to this condition is insulin, which plays a piv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/6/1294 |
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| author | Fahrul Nurkolis Rudy Kurniawan Elvan Wiyarta Rony Abdi Syahputra Reggie Surya Nurpudji Astuti Taslim Trina Ekawati Tallei Raymond Rubianto Tjandrawinata Eli Y. Adashi Bonglee Kim |
| author_facet | Fahrul Nurkolis Rudy Kurniawan Elvan Wiyarta Rony Abdi Syahputra Reggie Surya Nurpudji Astuti Taslim Trina Ekawati Tallei Raymond Rubianto Tjandrawinata Eli Y. Adashi Bonglee Kim |
| author_sort | Fahrul Nurkolis |
| collection | DOAJ |
| description | Diabetes, particularly type 2 diabetes (T2D), is the main component of metabolic syndrome. It is highly prevalent and has drastically increased with sedentary lifestyles, notably behaviors linked to ease of access and minimal physical activity. Central to this condition is insulin, which plays a pivotal role in regulating glucose levels in the body by aiding glucose uptake and storage in cells, and what happens to diabetes? In diabetes, there is a disruption and malfunction in insulin regulation. Despite numerous efforts, effectively addressing diabetes remains a challenge. This article explores the potential of photoactivatable drugs in diabetes treatment, with a focus on light-activated insulin. We discuss its advantages and significant implications. This article is expected to enrich the existing literature substantially, offering a comprehensive analysis of potential strategies for improving diabetes management. With its minimal physical intrusion, light-activated insulin promises to improve patient comfort and treatment adherence. It offers precise regulation and localized impact, potentially mitigating the risks associated with conventional diabetes treatments. Additionally, light-activated insulin is capable of explicitly targeting RNA and epigenetic factors. This innovative approach may pave the way for more personalized and effective diabetes treatments, addressing not only the symptoms but also the underlying biological causes of the disease. The advancement of light-activated insulin could revolutionize diabetes management. This study represents a pioneering introduction to this novel modality for diabetes management. |
| first_indexed | 2024-04-24T17:58:14Z |
| format | Article |
| id | doaj.art-5879c2034f964ba9a260b7ec9602b5ec |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-24T17:58:14Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5879c2034f964ba9a260b7ec9602b5ec2024-03-27T13:56:57ZengMDPI AGMolecules1420-30492024-03-01296129410.3390/molecules29061294Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes ManagementFahrul Nurkolis0Rudy Kurniawan1Elvan Wiyarta2Rony Abdi Syahputra3Reggie Surya4Nurpudji Astuti Taslim5Trina Ekawati Tallei6Raymond Rubianto Tjandrawinata7Eli Y. Adashi8Bonglee Kim9Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta 55281, IndonesiaGraduated School of Medicine, Faculty of Medicine, Hasanuddin University, Makassar 90245, IndonesiaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Hospital, Jakarta 10430, IndonesiaDepartment of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, IndonesiaDepartment of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta 11480, IndonesiaDivision of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar 90245, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Manado 95115, IndonesiaDepartment of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, IndonesiaWarren Alpert Medical School, Brown University, Providence, RI 02903, USADepartment of Pathology, College of Korean Medicine, Kyung Hee University, Kyungheedae-Ro 26, Dongdaemun-gu, Seoul 05254, Republic of KoreaDiabetes, particularly type 2 diabetes (T2D), is the main component of metabolic syndrome. It is highly prevalent and has drastically increased with sedentary lifestyles, notably behaviors linked to ease of access and minimal physical activity. Central to this condition is insulin, which plays a pivotal role in regulating glucose levels in the body by aiding glucose uptake and storage in cells, and what happens to diabetes? In diabetes, there is a disruption and malfunction in insulin regulation. Despite numerous efforts, effectively addressing diabetes remains a challenge. This article explores the potential of photoactivatable drugs in diabetes treatment, with a focus on light-activated insulin. We discuss its advantages and significant implications. This article is expected to enrich the existing literature substantially, offering a comprehensive analysis of potential strategies for improving diabetes management. With its minimal physical intrusion, light-activated insulin promises to improve patient comfort and treatment adherence. It offers precise regulation and localized impact, potentially mitigating the risks associated with conventional diabetes treatments. Additionally, light-activated insulin is capable of explicitly targeting RNA and epigenetic factors. This innovative approach may pave the way for more personalized and effective diabetes treatments, addressing not only the symptoms but also the underlying biological causes of the disease. The advancement of light-activated insulin could revolutionize diabetes management. This study represents a pioneering introduction to this novel modality for diabetes management.https://www.mdpi.com/1420-3049/29/6/1294blood glucosephotoactivatable drugsinsulindiabeteshyperglycemia |
| spellingShingle | Fahrul Nurkolis Rudy Kurniawan Elvan Wiyarta Rony Abdi Syahputra Reggie Surya Nurpudji Astuti Taslim Trina Ekawati Tallei Raymond Rubianto Tjandrawinata Eli Y. Adashi Bonglee Kim Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management Molecules blood glucose photoactivatable drugs insulin diabetes hyperglycemia |
| title | Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management |
| title_full | Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management |
| title_fullStr | Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management |
| title_full_unstemmed | Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management |
| title_short | Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management |
| title_sort | unraveling light activated insulin action in regulating blood glucose new photoactivatable insight as a novel modality in diabetes management |
| topic | blood glucose photoactivatable drugs insulin diabetes hyperglycemia |
| url | https://www.mdpi.com/1420-3049/29/6/1294 |
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