Simulated microgravity increases CD226+Lin−CD117−Sca1+ mesenchymal stem cells in mice
Abstract Microgravity is one of the most common causes counting for the bone loss. Mesenchymal stem cells (MSCs) contribute greatly to the differentiation and function of bone related cells. The development of novel MSCs biomarkers is critical for implementing effective therapies for microgravity in...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15971 |
| _version_ | 1797262570995843072 |
|---|---|
| author | Wenjing Zhou Yi Li Yongli Hou Wenli Dan Lihua Chen Fei Shi Fang Zhao Liang Fang |
| author_facet | Wenjing Zhou Yi Li Yongli Hou Wenli Dan Lihua Chen Fei Shi Fang Zhao Liang Fang |
| author_sort | Wenjing Zhou |
| collection | DOAJ |
| description | Abstract Microgravity is one of the most common causes counting for the bone loss. Mesenchymal stem cells (MSCs) contribute greatly to the differentiation and function of bone related cells. The development of novel MSCs biomarkers is critical for implementing effective therapies for microgravity induced bone loss. We aimed to find the new molecules involved in the differentiation and function of MSCs in mouse simulated microgravity model. We found CD226 was preferentially expressed on a subset of MSCs. Simulation of microgravity treatment significantly increased the proportion of CD226+Lin−CD117−Sca1+ MSCs. The CD226+ MSCs produced higher IL‐6, M‐CSF, RANKL and lower CD200 expression, and promoted osteoclast differentiation. This study provides pivotal information to understand the role of CD226 in MSCs, and inspires new ideas for prevention of bone loss related diseases. |
| first_indexed | 2024-04-24T23:59:13Z |
| format | Article |
| id | doaj.art-587a8e8235744aaba74eb2079261ae85 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-04-24T23:59:13Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-587a8e8235744aaba74eb2079261ae852024-03-14T08:20:44ZengWileyPhysiological Reports2051-817X2024-03-01125n/an/a10.14814/phy2.15971Simulated microgravity increases CD226+Lin−CD117−Sca1+ mesenchymal stem cells in miceWenjing Zhou0Yi Li1Yongli Hou2Wenli Dan3Lihua Chen4Fei Shi5Fang Zhao6Liang Fang7College of Life Sciences, Northwest University Xi’ an ChinaDepartment of Immunology Fourth Military Medical University Xi'an ChinaDepartment of Immunology Fourth Military Medical University Xi'an ChinaDepartment of Immunology Fourth Military Medical University Xi'an ChinaDepartment of Immunology Fourth Military Medical University Xi'an ChinaThe Key Laboratory of Aerospace Medicine, Ministry of Education Fourth Military Medical University Xi'an ChinaDepartment of Occupational and Environmental Health, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health, Fourth Military Medical University Xi'an ChinaDepartment of Immunology Fourth Military Medical University Xi'an ChinaAbstract Microgravity is one of the most common causes counting for the bone loss. Mesenchymal stem cells (MSCs) contribute greatly to the differentiation and function of bone related cells. The development of novel MSCs biomarkers is critical for implementing effective therapies for microgravity induced bone loss. We aimed to find the new molecules involved in the differentiation and function of MSCs in mouse simulated microgravity model. We found CD226 was preferentially expressed on a subset of MSCs. Simulation of microgravity treatment significantly increased the proportion of CD226+Lin−CD117−Sca1+ MSCs. The CD226+ MSCs produced higher IL‐6, M‐CSF, RANKL and lower CD200 expression, and promoted osteoclast differentiation. This study provides pivotal information to understand the role of CD226 in MSCs, and inspires new ideas for prevention of bone loss related diseases.https://doi.org/10.14814/phy2.15971biomarkerCD226mesenchymal stem cellsimulated microgravity |
| spellingShingle | Wenjing Zhou Yi Li Yongli Hou Wenli Dan Lihua Chen Fei Shi Fang Zhao Liang Fang Simulated microgravity increases CD226+Lin−CD117−Sca1+ mesenchymal stem cells in mice Physiological Reports biomarker CD226 mesenchymal stem cell simulated microgravity |
| title | Simulated microgravity increases CD226+Lin−CD117−Sca1+ mesenchymal stem cells in mice |
| title_full | Simulated microgravity increases CD226+Lin−CD117−Sca1+ mesenchymal stem cells in mice |
| title_fullStr | Simulated microgravity increases CD226+Lin−CD117−Sca1+ mesenchymal stem cells in mice |
| title_full_unstemmed | Simulated microgravity increases CD226+Lin−CD117−Sca1+ mesenchymal stem cells in mice |
| title_short | Simulated microgravity increases CD226+Lin−CD117−Sca1+ mesenchymal stem cells in mice |
| title_sort | simulated microgravity increases cd226 lin cd117 sca1 mesenchymal stem cells in mice |
| topic | biomarker CD226 mesenchymal stem cell simulated microgravity |
| url | https://doi.org/10.14814/phy2.15971 |
| work_keys_str_mv | AT wenjingzhou simulatedmicrogravityincreasescd226lincd117sca1mesenchymalstemcellsinmice AT yili simulatedmicrogravityincreasescd226lincd117sca1mesenchymalstemcellsinmice AT yonglihou simulatedmicrogravityincreasescd226lincd117sca1mesenchymalstemcellsinmice AT wenlidan simulatedmicrogravityincreasescd226lincd117sca1mesenchymalstemcellsinmice AT lihuachen simulatedmicrogravityincreasescd226lincd117sca1mesenchymalstemcellsinmice AT feishi simulatedmicrogravityincreasescd226lincd117sca1mesenchymalstemcellsinmice AT fangzhao simulatedmicrogravityincreasescd226lincd117sca1mesenchymalstemcellsinmice AT liangfang simulatedmicrogravityincreasescd226lincd117sca1mesenchymalstemcellsinmice |