Osmotherapy in patients with severe brain trauma
Traumatic brain injury is still a major cause of mortality and morbidity in the world and is considered a public health problem that needs to be well attended to. Cerebral oedema due to brain injury compromises the delivery of essential nutrients and alters normal intracranial pressure, whose incre...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
London Academic Publishing
2022-03-01
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| Series: | Romanian Neurosurgery |
| Subjects: | |
| Online Access: | http://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/2113 |
| _version_ | 1828343612388147200 |
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| author | Randy Reina-Rivero Gustavo Gaitán-Herrera Aixa Eliana García-García Amalia Molina-Trujillo Manuel Alejandro Jaramillo-Acosta Juliana Paniagua-Aguirre Alfonso Barón-Sánchez Antonio Luis Castro-Castro Mohamed Argüello-Manrique Michael Gregorio Ortega Sierra |
| author_facet | Randy Reina-Rivero Gustavo Gaitán-Herrera Aixa Eliana García-García Amalia Molina-Trujillo Manuel Alejandro Jaramillo-Acosta Juliana Paniagua-Aguirre Alfonso Barón-Sánchez Antonio Luis Castro-Castro Mohamed Argüello-Manrique Michael Gregorio Ortega Sierra |
| author_sort | Randy Reina-Rivero |
| collection | DOAJ |
| description |
Traumatic brain injury is still a major cause of mortality and morbidity in the world and is considered a public health problem that needs to be well attended to. Cerebral oedema due to brain injury compromises the delivery of essential nutrients and alters normal intracranial pressure, whose increase has been shown to be strongly associated with poor neurological outcomes and mortality for patients with head trauma. Intravenous fluids are a fundamental component of trauma care and fluid management influences patient outcomes. Thanks to advances in the research of osmotic agents, mortality has been reduced and there has been greater control in intracranial pressure. The osmotic agents most used for the control of intracranial pressure in patients who have suffered severe brain trauma are mannitol and hypertonic saline. However, in recent years have been studying the benefits that sodium lactate can generate in these cases. It has been found that sodium lactate has generated a greater decrease in intracranial pressure values and lower mortality rates with respect to mannitol and hypertonic saline. This still has been disputed as an application of mannitol, hypertonic saline or sodium lactate for treating patients who have suffered some head trauma. This review aims to show the advantages, disadvantages and recommendations of the different hyperosmolar solutions mentioned previously based on current evidence.
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| first_indexed | 2024-04-13T23:45:16Z |
| format | Article |
| id | doaj.art-587dfcaa3f594551aac80125878ab37c |
| institution | Directory Open Access Journal |
| issn | 1220-8841 2344-4959 |
| language | English |
| last_indexed | 2024-04-13T23:45:16Z |
| publishDate | 2022-03-01 |
| publisher | London Academic Publishing |
| record_format | Article |
| series | Romanian Neurosurgery |
| spelling | doaj.art-587dfcaa3f594551aac80125878ab37c2022-12-22T02:24:21ZengLondon Academic PublishingRomanian Neurosurgery1220-88412344-49592022-03-01361Osmotherapy in patients with severe brain traumaRandy Reina-Rivero0Gustavo Gaitán-HerreraAixa Eliana García-GarcíaAmalia Molina-TrujilloManuel Alejandro Jaramillo-AcostaJuliana Paniagua-AguirreAlfonso Barón-SánchezAntonio Luis Castro-CastroMohamed Argüello-ManriqueMichael Gregorio Ortega SierraUniversidad de Cartagena Traumatic brain injury is still a major cause of mortality and morbidity in the world and is considered a public health problem that needs to be well attended to. Cerebral oedema due to brain injury compromises the delivery of essential nutrients and alters normal intracranial pressure, whose increase has been shown to be strongly associated with poor neurological outcomes and mortality for patients with head trauma. Intravenous fluids are a fundamental component of trauma care and fluid management influences patient outcomes. Thanks to advances in the research of osmotic agents, mortality has been reduced and there has been greater control in intracranial pressure. The osmotic agents most used for the control of intracranial pressure in patients who have suffered severe brain trauma are mannitol and hypertonic saline. However, in recent years have been studying the benefits that sodium lactate can generate in these cases. It has been found that sodium lactate has generated a greater decrease in intracranial pressure values and lower mortality rates with respect to mannitol and hypertonic saline. This still has been disputed as an application of mannitol, hypertonic saline or sodium lactate for treating patients who have suffered some head trauma. This review aims to show the advantages, disadvantages and recommendations of the different hyperosmolar solutions mentioned previously based on current evidence. http://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/2113osmotherapytraumatic brain injuryintracranial pressuremannitolsodium lactatehypertonic saline solution |
| spellingShingle | Randy Reina-Rivero Gustavo Gaitán-Herrera Aixa Eliana García-García Amalia Molina-Trujillo Manuel Alejandro Jaramillo-Acosta Juliana Paniagua-Aguirre Alfonso Barón-Sánchez Antonio Luis Castro-Castro Mohamed Argüello-Manrique Michael Gregorio Ortega Sierra Osmotherapy in patients with severe brain trauma Romanian Neurosurgery osmotherapy traumatic brain injury intracranial pressure mannitol sodium lactate hypertonic saline solution |
| title | Osmotherapy in patients with severe brain trauma |
| title_full | Osmotherapy in patients with severe brain trauma |
| title_fullStr | Osmotherapy in patients with severe brain trauma |
| title_full_unstemmed | Osmotherapy in patients with severe brain trauma |
| title_short | Osmotherapy in patients with severe brain trauma |
| title_sort | osmotherapy in patients with severe brain trauma |
| topic | osmotherapy traumatic brain injury intracranial pressure mannitol sodium lactate hypertonic saline solution |
| url | http://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/2113 |
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