Modulation of dendritic cell metabolism by an MPLA-adjuvanted allergen product for specific immunotherapy

Modulation of dendritic cell metabolism by an MPLA-adjuvanted allergen product for specific immunotherapy

BackgroundRecently, bacterial components were shown to enhance immune responses by shifting immune cell metabolism towards glycolysis and lactic acid production, also known as the Warburg Effect. Currently, the effect of allergen products for immunotherapy (AIT) and commercial vaccines on immune cel...

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Bibliographic Details
Main Authors: Jennifer Zimmermann, Alexandra Goretzki, Clara Meier, Sonja Wolfheimer, Yen-Ju Lin, Hannah Rainer, Maren Krause, Saskia Wedel, Gerd Spies, Frank Führer, Stefan Vieths, Stephan Scheurer, Stefan Schülke
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
MPLA: monophosphoryl lipid A
immune metabolism
Warburg Effect
allergen specific immunotherapy
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.916491/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.916491/full

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