Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare disease and review of the literature
Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic tumor, first described by Shih and Kurman in 1998. ETT often present as abnormal vaginal bleeding in women of reproductive age, but unlike more common forms of GTN tend to produce much less human chorionic gonadotropin (hCG) f...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578923002989 |
| _version_ | 1797669898403446784 |
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| author | M. Helbig M. Steinmann S. Jaschinski M.J. Seckl W. Meier T. Fehm A.K. Volkmer |
| author_facet | M. Helbig M. Steinmann S. Jaschinski M.J. Seckl W. Meier T. Fehm A.K. Volkmer |
| author_sort | M. Helbig |
| collection | DOAJ |
| description | Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic tumor, first described by Shih and Kurman in 1998. ETT often present as abnormal vaginal bleeding in women of reproductive age, but unlike more common forms of GTN tend to produce much less human chorionic gonadotropin (hCG) for the volume of disease present. ETT can occur after any gestational event and can occur in both intrauterine and extrauterine sites. We present a case of a 46-year-old female patient incidentally diagnosed with ETT and hepatic metastasis. Therapy was multimodal and involved chemotherapy, operation, thermoablation of liver metastases and immunocheckpoint inhibitor. The patient remains disease free for almost four years now. ETT presents a diagnostic challenge due to their rarity and histologic resemblance to other pathologies. ETT can be relatively chemo resistant and are therefore often treated surgically. Misdiagnosis might delay effective treatment and affects survival. |
| first_indexed | 2024-03-11T20:51:33Z |
| format | Article |
| id | doaj.art-58859e5d4f9c4614945115ac2e0c5bbb |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-03-11T20:51:33Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-58859e5d4f9c4614945115ac2e0c5bbb2023-10-01T05:58:32ZengElsevierGynecologic Oncology Reports2352-57892023-10-0149101281Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare disease and review of the literatureM. Helbig0M. Steinmann1S. Jaschinski2M.J. Seckl3W. Meier4T. Fehm5A.K. Volkmer6University Hospital of Düsseldorf, Department of Gynecology and Obstetrics, Germany; Corresponding author.Medical Practice for Gynecology and Obstetrics, Düsseldorf, GermanyUniversity Hospital of Düsseldorf, Institute of Pathology, GermanyGestational Trophoblastic Disease and Malignant Ovarian Germ Cell Tumor Services, Charing Cross Hospital Campus of Imperial College London, London, UKUniversity Hospital of Düsseldorf, Department of Gynecology and Obstetrics, GermanyUniversity Hospital of Düsseldorf, Department of Gynecology and Obstetrics, GermanyUniversity Hospital of Düsseldorf, Department of Gynecology and Obstetrics, GermanyEpithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic tumor, first described by Shih and Kurman in 1998. ETT often present as abnormal vaginal bleeding in women of reproductive age, but unlike more common forms of GTN tend to produce much less human chorionic gonadotropin (hCG) for the volume of disease present. ETT can occur after any gestational event and can occur in both intrauterine and extrauterine sites. We present a case of a 46-year-old female patient incidentally diagnosed with ETT and hepatic metastasis. Therapy was multimodal and involved chemotherapy, operation, thermoablation of liver metastases and immunocheckpoint inhibitor. The patient remains disease free for almost four years now. ETT presents a diagnostic challenge due to their rarity and histologic resemblance to other pathologies. ETT can be relatively chemo resistant and are therefore often treated surgically. Misdiagnosis might delay effective treatment and affects survival.http://www.sciencedirect.com/science/article/pii/S2352578923002989Epitheloid trophoblastic tumorETTGTN |
| spellingShingle | M. Helbig M. Steinmann S. Jaschinski M.J. Seckl W. Meier T. Fehm A.K. Volkmer Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare disease and review of the literature Gynecologic Oncology Reports Epitheloid trophoblastic tumor ETT GTN |
| title | Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare disease and review of the literature |
| title_full | Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare disease and review of the literature |
| title_fullStr | Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare disease and review of the literature |
| title_full_unstemmed | Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare disease and review of the literature |
| title_short | Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare disease and review of the literature |
| title_sort | primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation case report of an extremely rare disease and review of the literature |
| topic | Epitheloid trophoblastic tumor ETT GTN |
| url | http://www.sciencedirect.com/science/article/pii/S2352578923002989 |
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