Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update
Pancreatic β-cells and the liver play a key role in glucose homeostasis. After a meal or in a state of hyperglycemia, glucose is transported into the β-cells or hepatocytes where it is metabolized. In the β-cells, glucose is metabolized to increase the ATP:ADP ratio, resulting in the secretion of in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-05-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/10/5/5031/ |
| _version_ | 1811264200998125568 |
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| author | Jin-Sik Bae Tae-Hyun Kim Mi-Young Kim Joo-Man Park Yong-Ho Ahn |
| author_facet | Jin-Sik Bae Tae-Hyun Kim Mi-Young Kim Joo-Man Park Yong-Ho Ahn |
| author_sort | Jin-Sik Bae |
| collection | DOAJ |
| description | Pancreatic β-cells and the liver play a key role in glucose homeostasis. After a meal or in a state of hyperglycemia, glucose is transported into the β-cells or hepatocytes where it is metabolized. In the β-cells, glucose is metabolized to increase the ATP:ADP ratio, resulting in the secretion of insulin stored in the vesicle. In the hepatocytes, glucose is metabolized to CO2, fatty acids or stored as glycogen. In these cells, solute carrier family 2 (SLC2A2) and glucokinase play a key role in sensing and uptaking glucose. Dysfunction of these proteins results in the hyperglycemia which is one of the characteristics of type 2 diabetes mellitus (T2DM). Thus, studies on the molecular mechanisms of their transcriptional regulations are important in understanding pathogenesis and combating T2DM. In this paper, we will review a recent update on the progress of gene regulation of glucose sensors in the liver and β-cells. |
| first_indexed | 2024-04-12T19:58:54Z |
| format | Article |
| id | doaj.art-5886c512b6614010b6449b2653f2415e |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-12T19:58:54Z |
| publishDate | 2010-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-5886c512b6614010b6449b2653f2415e2022-12-22T03:18:35ZengMDPI AGSensors1424-82202010-05-011055031505310.3390/s100505031Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An UpdateJin-Sik BaeTae-Hyun KimMi-Young KimJoo-Man ParkYong-Ho AhnPancreatic β-cells and the liver play a key role in glucose homeostasis. After a meal or in a state of hyperglycemia, glucose is transported into the β-cells or hepatocytes where it is metabolized. In the β-cells, glucose is metabolized to increase the ATP:ADP ratio, resulting in the secretion of insulin stored in the vesicle. In the hepatocytes, glucose is metabolized to CO2, fatty acids or stored as glycogen. In these cells, solute carrier family 2 (SLC2A2) and glucokinase play a key role in sensing and uptaking glucose. Dysfunction of these proteins results in the hyperglycemia which is one of the characteristics of type 2 diabetes mellitus (T2DM). Thus, studies on the molecular mechanisms of their transcriptional regulations are important in understanding pathogenesis and combating T2DM. In this paper, we will review a recent update on the progress of gene regulation of glucose sensors in the liver and β-cells.http://www.mdpi.com/1424-8220/10/5/5031/glucose sensorsolute carrier family 2 (SLC2A2)glucokinase (GCK)transcriptionliverpancreatic β-cell |
| spellingShingle | Jin-Sik Bae Tae-Hyun Kim Mi-Young Kim Joo-Man Park Yong-Ho Ahn Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update Sensors glucose sensor solute carrier family 2 (SLC2A2) glucokinase (GCK) transcription liver pancreatic β-cell |
| title | Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update |
| title_full | Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update |
| title_fullStr | Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update |
| title_full_unstemmed | Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update |
| title_short | Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update |
| title_sort | transcriptional regulation of glucose sensors in pancreatic β cells and liver an update |
| topic | glucose sensor solute carrier family 2 (SLC2A2) glucokinase (GCK) transcription liver pancreatic β-cell |
| url | http://www.mdpi.com/1424-8220/10/5/5031/ |
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