Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer
Abstract The ability of sibling embryos to form blastocysts may reflect the developmental potential of the embryos that were transferred into the uterus. The purpose of the study was to investigate whether the development speed of sibling embryos positively reflects the live birth rate following fre...
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| Format: | Article |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33573-6 |
| _version_ | 1797841002630742016 |
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| author | Xue Wang Yaling Xiao Yuanzheng Zhou Hanbi Wang |
| author_facet | Xue Wang Yaling Xiao Yuanzheng Zhou Hanbi Wang |
| author_sort | Xue Wang |
| collection | DOAJ |
| description | Abstract The ability of sibling embryos to form blastocysts may reflect the developmental potential of the embryos that were transferred into the uterus. The purpose of the study was to investigate whether the development speed of sibling embryos positively reflects the live birth rate following fresh embryo transfer. We examined 1262 cycles of women who underwent day 3 (D3) cleavage embryo transfer in the Peking Union Medical College Hospital in 2015–2020, who were divided into three groups (D5, D5 + D6, and D6) according to blastocyst formation. The live birth rate in patients with blastocysts that formed on D6 was significantly lower than the other two groups (36.1%, 45.6% and 44.7%, P < 0.05). For women with blastocysts that formed on D6, the live birth rate was higher in those with more good quality blastocysts than poor-quality blastocysts (42.4 vs 32.3%, P < 0.05). Multiple regression analysis showed that the blastocyst development speed of sibling embryos was an independent factor affecting live birth after fresh embryo transfer (P < 0.05). We concluded that the blastocyst development speed of sibling embryos may reflect live birth rate following the transfer of D3 cleavage embryos. |
| first_indexed | 2024-04-09T16:23:51Z |
| format | Article |
| id | doaj.art-588a812a71b84e0b9a6593752b5a2b91 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T16:23:51Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
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| spelling | doaj.art-588a812a71b84e0b9a6593752b5a2b912023-04-23T11:17:20ZengNature PortfolioScientific Reports2045-23222023-04-011311710.1038/s41598-023-33573-6Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transferXue Wang0Yaling Xiao1Yuanzheng Zhou2Hanbi Wang3Department of Gynaecology Endocrine and Reproductive Centre, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Gynaecology Endocrine and Reproductive Centre, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Gynaecology Endocrine and Reproductive Centre, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Gynaecology Endocrine and Reproductive Centre, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract The ability of sibling embryos to form blastocysts may reflect the developmental potential of the embryos that were transferred into the uterus. The purpose of the study was to investigate whether the development speed of sibling embryos positively reflects the live birth rate following fresh embryo transfer. We examined 1262 cycles of women who underwent day 3 (D3) cleavage embryo transfer in the Peking Union Medical College Hospital in 2015–2020, who were divided into three groups (D5, D5 + D6, and D6) according to blastocyst formation. The live birth rate in patients with blastocysts that formed on D6 was significantly lower than the other two groups (36.1%, 45.6% and 44.7%, P < 0.05). For women with blastocysts that formed on D6, the live birth rate was higher in those with more good quality blastocysts than poor-quality blastocysts (42.4 vs 32.3%, P < 0.05). Multiple regression analysis showed that the blastocyst development speed of sibling embryos was an independent factor affecting live birth after fresh embryo transfer (P < 0.05). We concluded that the blastocyst development speed of sibling embryos may reflect live birth rate following the transfer of D3 cleavage embryos.https://doi.org/10.1038/s41598-023-33573-6 |
| spellingShingle | Xue Wang Yaling Xiao Yuanzheng Zhou Hanbi Wang Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer Scientific Reports |
| title | Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer |
| title_full | Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer |
| title_fullStr | Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer |
| title_full_unstemmed | Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer |
| title_short | Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer |
| title_sort | development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer |
| url | https://doi.org/10.1038/s41598-023-33573-6 |
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