Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women
Abstract Introduction Possible joint effects of subjective cognitive decline (SCD) and apolipoprotein E (APOE) ε4 genotype on incident mild cognitive impairment (MCI) were examined for men and women separately. Methods Cognitively normal participants with and without SCD were included from the first...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-12-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2019.01.007 |
| _version_ | 1819106281270542336 |
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| author | Diana Müller‐Gerards Christian Weimar Jessica Abramowski Sarah Tebrügge Martha Jokisch Nico Dragano Raimund Erbel Karl‐Heinz Jöckel Susanne Moebus Angela Winkler Heinz Nixdorf Recall Study Investigative Group |
| author_facet | Diana Müller‐Gerards Christian Weimar Jessica Abramowski Sarah Tebrügge Martha Jokisch Nico Dragano Raimund Erbel Karl‐Heinz Jöckel Susanne Moebus Angela Winkler Heinz Nixdorf Recall Study Investigative Group |
| author_sort | Diana Müller‐Gerards |
| collection | DOAJ |
| description | Abstract Introduction Possible joint effects of subjective cognitive decline (SCD) and apolipoprotein E (APOE) ε4 genotype on incident mild cognitive impairment (MCI) were examined for men and women separately. Methods Cognitively normal participants with and without SCD were included from the first follow‐up examination of the population‐based Heinz Nixdorf Recall study. Sex‐stratified logistic regression models estimated main effects and interactions (additive, multiplicative) of SCD at the first follow‐up (yes+/no−) and APOE ε4 (positive+/negative−) groups for MCI 5 years later. Results Odds for MCI 5 years later were higher in SCD/APOE ε4 group +/+ than the sum of groups +/− and −/+ in women, with a trend for positive interaction. Odds for incident MCI in men was highest in group +/−, with no interaction effect. Discussion Our findings indicate that APOE ε4 may play an important role in the association of SCD and incident MCI, especially considering sex. Further studies need to examine these associations with larger sample sizes. |
| first_indexed | 2024-12-22T02:35:39Z |
| format | Article |
| id | doaj.art-588b1aa9a9414398900eaebbc03ff835 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-22T02:35:39Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-588b1aa9a9414398900eaebbc03ff8352022-12-21T18:41:46ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292019-12-0111122123010.1016/j.dadm.2019.01.007Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and womenDiana Müller‐Gerards0Christian Weimar1Jessica Abramowski2Sarah Tebrügge3Martha Jokisch4Nico Dragano5Raimund Erbel6Karl‐Heinz Jöckel7Susanne Moebus8Angela Winkler9Heinz Nixdorf Recall Study Investigative Group10Department of NeurologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyDepartment of NeurologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyDepartment of NeurologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyDepartment of NeurologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyDepartment of NeurologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyInstitute of Medical SociologyCentre for Health and SocietyUniversity of DüsseldorfMedical FacultyUniversity of DüsseldorfDüsseldorfGermanyInstitute of Medical InformaticsBiometrics and EpidemiologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyInstitute of Medical InformaticsBiometrics and EpidemiologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyInstitute of Medical InformaticsBiometrics and EpidemiologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyDepartment of NeurologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyDepartment of NeurologyUniversity Hospital Essen, University of Duisburg‐EssenEssenGermanyAbstract Introduction Possible joint effects of subjective cognitive decline (SCD) and apolipoprotein E (APOE) ε4 genotype on incident mild cognitive impairment (MCI) were examined for men and women separately. Methods Cognitively normal participants with and without SCD were included from the first follow‐up examination of the population‐based Heinz Nixdorf Recall study. Sex‐stratified logistic regression models estimated main effects and interactions (additive, multiplicative) of SCD at the first follow‐up (yes+/no−) and APOE ε4 (positive+/negative−) groups for MCI 5 years later. Results Odds for MCI 5 years later were higher in SCD/APOE ε4 group +/+ than the sum of groups +/− and −/+ in women, with a trend for positive interaction. Odds for incident MCI in men was highest in group +/−, with no interaction effect. Discussion Our findings indicate that APOE ε4 may play an important role in the association of SCD and incident MCI, especially considering sex. Further studies need to examine these associations with larger sample sizes.https://doi.org/10.1016/j.dadm.2019.01.007APOEmild cognitive impairmentPopulation‐basedsexsubjective cognitive decline |
| spellingShingle | Diana Müller‐Gerards Christian Weimar Jessica Abramowski Sarah Tebrügge Martha Jokisch Nico Dragano Raimund Erbel Karl‐Heinz Jöckel Susanne Moebus Angela Winkler Heinz Nixdorf Recall Study Investigative Group Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring APOE mild cognitive impairment Population‐based sex subjective cognitive decline |
| title | Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women |
| title_full | Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women |
| title_fullStr | Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women |
| title_full_unstemmed | Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women |
| title_short | Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women |
| title_sort | subjective cognitive decline apoe ε4 and incident mild cognitive impairment in men and women |
| topic | APOE mild cognitive impairment Population‐based sex subjective cognitive decline |
| url | https://doi.org/10.1016/j.dadm.2019.01.007 |
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