Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer
Objective This study investigated immunohistochemical staining results of two cytoskeletal proteins (vimentin and cytokeratin-18) and two extracellular matrix proteins (fibronectin-1 and laminin-1 receptor) in different stages of triple negative breast cancer. Methods Forty triple negative cancerous...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-11-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060519877079 |
| _version_ | 1818966753588281344 |
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| author | Mohammed Elimam Ahamed Mohammed Nuha Mohammed Elhassan |
| author_facet | Mohammed Elimam Ahamed Mohammed Nuha Mohammed Elhassan |
| author_sort | Mohammed Elimam Ahamed Mohammed |
| collection | DOAJ |
| description | Objective This study investigated immunohistochemical staining results of two cytoskeletal proteins (vimentin and cytokeratin-18) and two extracellular matrix proteins (fibronectin-1 and laminin-1 receptor) in different stages of triple negative breast cancer. Methods Forty triple negative cancerous breast tissues from patients diagnosed as stage 2A (15), 2B (nine), 3A (10), 3B (four), and 3C (two) were included in this study and were compared with 42 normal breast tissues. Immunohistochemistry results were statistically analyzed using the t-test percent of the StatPac program. Results The percentages of positive staining in cancerous tissues for all of the studied parameters were significantly greater than their percentages in normal tissues, except for vimentin. All cancerous tissues from patients diagnosed as stage 3A, 3B, and 3C were positive for both fibronectin-1 and laminin-1 receptor. Conclusion Fibronectin-1 and laminin-1 receptor are promising markers for stage 3 triple negative breast cancer. |
| first_indexed | 2024-12-20T13:37:55Z |
| format | Article |
| id | doaj.art-588c158633124f73b6f85df3e8394740 |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-20T13:37:55Z |
| publishDate | 2019-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-588c158633124f73b6f85df3e83947402022-12-21T19:38:52ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002019-11-014710.1177/0300060519877079Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancerMohammed Elimam Ahamed MohammedNuha Mohammed ElhassanObjective This study investigated immunohistochemical staining results of two cytoskeletal proteins (vimentin and cytokeratin-18) and two extracellular matrix proteins (fibronectin-1 and laminin-1 receptor) in different stages of triple negative breast cancer. Methods Forty triple negative cancerous breast tissues from patients diagnosed as stage 2A (15), 2B (nine), 3A (10), 3B (four), and 3C (two) were included in this study and were compared with 42 normal breast tissues. Immunohistochemistry results were statistically analyzed using the t-test percent of the StatPac program. Results The percentages of positive staining in cancerous tissues for all of the studied parameters were significantly greater than their percentages in normal tissues, except for vimentin. All cancerous tissues from patients diagnosed as stage 3A, 3B, and 3C were positive for both fibronectin-1 and laminin-1 receptor. Conclusion Fibronectin-1 and laminin-1 receptor are promising markers for stage 3 triple negative breast cancer.https://doi.org/10.1177/0300060519877079 |
| spellingShingle | Mohammed Elimam Ahamed Mohammed Nuha Mohammed Elhassan Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer Journal of International Medical Research |
| title | Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer |
| title_full | Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer |
| title_fullStr | Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer |
| title_full_unstemmed | Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer |
| title_short | Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer |
| title_sort | cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer |
| url | https://doi.org/10.1177/0300060519877079 |
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