Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer

Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer

Abstract Delivery of nucleic acids into solid tumor environments remains a pressing challenge. This study examines the ability of macrophages to horizontally transfer small interfering RNA (siRNA) lipoplexes to cancer cells. Macrophages are a natural candidate for a drug carrier because of their abi...

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Bibliographic Details
Main Authors: Elizabeth C. Wayne, Christian Long, Matthew J. Haney, Elena V. Batrakova, Tina M. Leisner, Leslie V. Parise, Alexander V. Kabanov
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Advanced Science
Subjects:
cancer
gene delivery
immunotherapy
macrophages
small interfering RNA (siRNA)
Online Access:https://doi.org/10.1002/advs.201900582

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