Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients
Abstract Objectives The purpose of this study was to assess the impact of polypharmacy, potentially inappropriate medications, and drug-drug interactions on in-hospital mortality in older COVID-19 inpatients. Methods A cross-sectional study was conducted using electronic medical data from a tertiary...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04487-9 |
| _version_ | 1827633191794507776 |
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| author | Zhaoyan Chen Fangyuan Tian Ya Zeng |
| author_facet | Zhaoyan Chen Fangyuan Tian Ya Zeng |
| author_sort | Zhaoyan Chen |
| collection | DOAJ |
| description | Abstract Objectives The purpose of this study was to assess the impact of polypharmacy, potentially inappropriate medications, and drug-drug interactions on in-hospital mortality in older COVID-19 inpatients. Methods A cross-sectional study was conducted using electronic medical data from a tertiary hospital in Chengdu from December 2022 to January 2023. The 2019 AGS/Beers criteria was used to evaluate the potentially inappropriate mediation (PIM) status of older COVID-19 inpatients (age ≥ 65 years), the drug-drug interactions were evaluated on Medscape, and multivariate logistic regression was used to identify the risk factors associated with in-hospital mortality. Results A total of 206 older COVID-19 inpatients were included in the study. The mean number of drugs per day was 13.04. The prevalence of PIM use based on the 2019 AGS Beers Criteria was 66.99%. The prevalence of drug-drug interactions was 61.65%. Logistic regression demonstrated that age ≥ 80 (OR: 10.321, 95% CI: 1.649, 64.579, P = 0.013), renal insufficiency (OR: 4.740, 95% CI: 1.366, 16.447, P = 0.014), long-term hospitalization (OR: 6.637, 95% CI: 1.030, 42.779, P = 0.046), severe pneumonia (OR: 50.230, 95% CI: 5.180, 487.041, P = 0.001) were influencing factors associated with in-hospital mortality in older COVID-19 inpatients. Conclusions The polypharmacy, potentially inappropriate medications, and drug-drug interactions were seen in many older COVID-19 inpatients. |
| first_indexed | 2024-03-09T14:56:04Z |
| format | Article |
| id | doaj.art-588ca8f94a29469d81eb290b065bfdc8 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-09T14:56:04Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-588ca8f94a29469d81eb290b065bfdc82023-11-26T14:10:44ZengBMCBMC Geriatrics1471-23182023-11-012311810.1186/s12877-023-04487-9Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatientsZhaoyan Chen0Fangyuan Tian1Ya Zeng2Department of Pharmacy, West China Hospital, Sichuan UniversityDepartment of Pharmacy, West China Hospital, Sichuan UniversityDepartment of Pharmacy, West China Hospital, Sichuan UniversityAbstract Objectives The purpose of this study was to assess the impact of polypharmacy, potentially inappropriate medications, and drug-drug interactions on in-hospital mortality in older COVID-19 inpatients. Methods A cross-sectional study was conducted using electronic medical data from a tertiary hospital in Chengdu from December 2022 to January 2023. The 2019 AGS/Beers criteria was used to evaluate the potentially inappropriate mediation (PIM) status of older COVID-19 inpatients (age ≥ 65 years), the drug-drug interactions were evaluated on Medscape, and multivariate logistic regression was used to identify the risk factors associated with in-hospital mortality. Results A total of 206 older COVID-19 inpatients were included in the study. The mean number of drugs per day was 13.04. The prevalence of PIM use based on the 2019 AGS Beers Criteria was 66.99%. The prevalence of drug-drug interactions was 61.65%. Logistic regression demonstrated that age ≥ 80 (OR: 10.321, 95% CI: 1.649, 64.579, P = 0.013), renal insufficiency (OR: 4.740, 95% CI: 1.366, 16.447, P = 0.014), long-term hospitalization (OR: 6.637, 95% CI: 1.030, 42.779, P = 0.046), severe pneumonia (OR: 50.230, 95% CI: 5.180, 487.041, P = 0.001) were influencing factors associated with in-hospital mortality in older COVID-19 inpatients. Conclusions The polypharmacy, potentially inappropriate medications, and drug-drug interactions were seen in many older COVID-19 inpatients.https://doi.org/10.1186/s12877-023-04487-9COVID-19Potentially inappropriate medicationsPolypharmacyOlderMortality |
| spellingShingle | Zhaoyan Chen Fangyuan Tian Ya Zeng Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients BMC Geriatrics COVID-19 Potentially inappropriate medications Polypharmacy Older Mortality |
| title | Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients |
| title_full | Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients |
| title_fullStr | Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients |
| title_full_unstemmed | Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients |
| title_short | Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients |
| title_sort | polypharmacy potentially inappropriate medications and drug drug interactions in older covid 19 inpatients |
| topic | COVID-19 Potentially inappropriate medications Polypharmacy Older Mortality |
| url | https://doi.org/10.1186/s12877-023-04487-9 |
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