Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics
Basal cell carcinoma (BCC) is a significant public health concern, with more than 3 million cases occurring each year in the United States, and with an increasing incidence. The molecular basis of BCC is complex, involving an interplay of inherited genetic susceptibility, including single nucleotide...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/15/3870 |
| _version_ | 1797525715946569728 |
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| author | James M. Kilgour Justin L. Jia Kavita Y. Sarin |
| author_facet | James M. Kilgour Justin L. Jia Kavita Y. Sarin |
| author_sort | James M. Kilgour |
| collection | DOAJ |
| description | Basal cell carcinoma (BCC) is a significant public health concern, with more than 3 million cases occurring each year in the United States, and with an increasing incidence. The molecular basis of BCC is complex, involving an interplay of inherited genetic susceptibility, including single nucleotide polymorphisms and genetic syndromes, and sporadic somatic mutations, often induced by carcinogenic exposure to UV radiation. This review outlines the currently known germline and somatic mutations implicated in the pathogenesis of BCC, including the key molecular pathways affected by these mutations, which drive oncogenesis. With advances in next generation sequencing and our understanding of the molecular genetics of BCC, established and emerging targeted therapeutics are offering new avenues for the non-surgical treatment of BCC. These agents, including Hedgehog pathway inhibitors, immune modulators, and histone deacetylase inhibitors, will also be discussed. |
| first_indexed | 2024-03-10T09:16:58Z |
| format | Article |
| id | doaj.art-58906a346a9c4d69893f19b389786625 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:16:58Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-58906a346a9c4d69893f19b3897866252023-11-22T05:29:14ZengMDPI AGCancers2072-66942021-07-011315387010.3390/cancers13153870Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted TherapeuticsJames M. Kilgour0Justin L. Jia1Kavita Y. Sarin2Department of Dermatology, Stanford University School of Medcine, Stanford, CA 94305, USADepartment of Dermatology, Stanford University School of Medcine, Stanford, CA 94305, USADepartment of Dermatology, Stanford University School of Medcine, Stanford, CA 94305, USABasal cell carcinoma (BCC) is a significant public health concern, with more than 3 million cases occurring each year in the United States, and with an increasing incidence. The molecular basis of BCC is complex, involving an interplay of inherited genetic susceptibility, including single nucleotide polymorphisms and genetic syndromes, and sporadic somatic mutations, often induced by carcinogenic exposure to UV radiation. This review outlines the currently known germline and somatic mutations implicated in the pathogenesis of BCC, including the key molecular pathways affected by these mutations, which drive oncogenesis. With advances in next generation sequencing and our understanding of the molecular genetics of BCC, established and emerging targeted therapeutics are offering new avenues for the non-surgical treatment of BCC. These agents, including Hedgehog pathway inhibitors, immune modulators, and histone deacetylase inhibitors, will also be discussed.https://www.mdpi.com/2072-6694/13/15/3870basal cell carcinomaskin neoplasmsdermatologyreviewmolecular geneticsgermline mutation |
| spellingShingle | James M. Kilgour Justin L. Jia Kavita Y. Sarin Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics Cancers basal cell carcinoma skin neoplasms dermatology review molecular genetics germline mutation |
| title | Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics |
| title_full | Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics |
| title_fullStr | Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics |
| title_full_unstemmed | Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics |
| title_short | Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics |
| title_sort | review of the molecular genetics of basal cell carcinoma inherited susceptibility somatic mutations and targeted therapeutics |
| topic | basal cell carcinoma skin neoplasms dermatology review molecular genetics germline mutation |
| url | https://www.mdpi.com/2072-6694/13/15/3870 |
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