The preclinical and clinical progress of cell sheet engineering in regenerative medicine
Abstract Cell therapy is an accessible method for curing damaged organs or tissues. Yet, this approach is limited by the delivery efficiency of cell suspension injection. Over recent years, biological scaffolds have emerged as carriers of delivering therapeutic cells to the target sites. Although th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03340-5 |
| _version_ | 1827956967787724800 |
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| author | Danping Hu Xinyu Li Jie Li Pei Tong Zhe Li Ge Lin Yi Sun Juan Wang |
| author_facet | Danping Hu Xinyu Li Jie Li Pei Tong Zhe Li Ge Lin Yi Sun Juan Wang |
| author_sort | Danping Hu |
| collection | DOAJ |
| description | Abstract Cell therapy is an accessible method for curing damaged organs or tissues. Yet, this approach is limited by the delivery efficiency of cell suspension injection. Over recent years, biological scaffolds have emerged as carriers of delivering therapeutic cells to the target sites. Although they can be regarded as revolutionary research output and promote the development of tissue engineering, the defect of biological scaffolds in repairing cell-dense tissues is apparent. Cell sheet engineering (CSE) is a novel technique that supports enzyme-free cell detachment in the shape of a sheet-like structure. Compared with the traditional method of enzymatic digestion, products harvested by this technique retain extracellular matrix (ECM) secreted by cells as well as cell-matrix and intercellular junctions established during in vitro culture. Herein, we discussed the current status and recent progress of CSE in basic research and clinical application by reviewing relevant articles that have been published, hoping to provide a reference for the development of CSE in the field of stem cells and regenerative medicine. |
| first_indexed | 2024-04-09T15:11:43Z |
| format | Article |
| id | doaj.art-5892e831b8384fb7ac1a722ca558e4d2 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-09T15:11:43Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-5892e831b8384fb7ac1a722ca558e4d22023-04-30T11:09:12ZengBMCStem Cell Research & Therapy1757-65122023-04-0114112310.1186/s13287-023-03340-5The preclinical and clinical progress of cell sheet engineering in regenerative medicineDanping Hu0Xinyu Li1Jie Li2Pei Tong3Zhe Li4Ge Lin5Yi Sun6Juan Wang7Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South UniversityInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South UniversityInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South UniversityHospital of Hunan Guangxiu, Medical College of Hunan Normal University, Hunan Normal UniversityInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South UniversityInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South UniversityInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South UniversityShanghai Biomass Pharmaceutical Product Evaluation Professional Public Service Platform, Center for Pharmacological Evaluation and Research, China State Institute of Pharmaceutical IndustryAbstract Cell therapy is an accessible method for curing damaged organs or tissues. Yet, this approach is limited by the delivery efficiency of cell suspension injection. Over recent years, biological scaffolds have emerged as carriers of delivering therapeutic cells to the target sites. Although they can be regarded as revolutionary research output and promote the development of tissue engineering, the defect of biological scaffolds in repairing cell-dense tissues is apparent. Cell sheet engineering (CSE) is a novel technique that supports enzyme-free cell detachment in the shape of a sheet-like structure. Compared with the traditional method of enzymatic digestion, products harvested by this technique retain extracellular matrix (ECM) secreted by cells as well as cell-matrix and intercellular junctions established during in vitro culture. Herein, we discussed the current status and recent progress of CSE in basic research and clinical application by reviewing relevant articles that have been published, hoping to provide a reference for the development of CSE in the field of stem cells and regenerative medicine.https://doi.org/10.1186/s13287-023-03340-5CSETissue engineeringPolymer materialsThree-dimensional structureStem cellRegenerative medicine |
| spellingShingle | Danping Hu Xinyu Li Jie Li Pei Tong Zhe Li Ge Lin Yi Sun Juan Wang The preclinical and clinical progress of cell sheet engineering in regenerative medicine Stem Cell Research & Therapy CSE Tissue engineering Polymer materials Three-dimensional structure Stem cell Regenerative medicine |
| title | The preclinical and clinical progress of cell sheet engineering in regenerative medicine |
| title_full | The preclinical and clinical progress of cell sheet engineering in regenerative medicine |
| title_fullStr | The preclinical and clinical progress of cell sheet engineering in regenerative medicine |
| title_full_unstemmed | The preclinical and clinical progress of cell sheet engineering in regenerative medicine |
| title_short | The preclinical and clinical progress of cell sheet engineering in regenerative medicine |
| title_sort | preclinical and clinical progress of cell sheet engineering in regenerative medicine |
| topic | CSE Tissue engineering Polymer materials Three-dimensional structure Stem cell Regenerative medicine |
| url | https://doi.org/10.1186/s13287-023-03340-5 |
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