Microencapsulation of Theobroma cacao L polyphenols: A high-value approach with in vitro anti-Trypanosoma cruzi, immunomodulatory and antioxidant activities
Chagas disease (CHD) is the highest economic burden parasitosis worldwide and the most important cardiac infection, without therapeutic alternatives to halt or reverse its progression. In CHD-experimental models, antioxidant and anti-inflammatory compounds have demonstrated therapeutic potential in...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224001884 |
| _version_ | 1797248410801143808 |
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| author | Laura Vargas-Munévar Juan Borja-Fajardo Angélica Sandoval-Aldana Wendy Quintero García Erika Moreno Moreno Juan Camilo Henriquez Elena Stashenko Liliana Torcoroma García Olimpo García-Beltrán |
| author_facet | Laura Vargas-Munévar Juan Borja-Fajardo Angélica Sandoval-Aldana Wendy Quintero García Erika Moreno Moreno Juan Camilo Henriquez Elena Stashenko Liliana Torcoroma García Olimpo García-Beltrán |
| author_sort | Laura Vargas-Munévar |
| collection | DOAJ |
| description | Chagas disease (CHD) is the highest economic burden parasitosis worldwide and the most important cardiac infection, without therapeutic alternatives to halt or reverse its progression. In CHD-experimental models, antioxidant and anti-inflammatory compounds have demonstrated therapeutic potential in cardiac dysfunction. Theobroma cacao polyphenols are potent natural antioxidants with cardioprotective and anti-inflammatory action, which are susceptible to degradation, requiring technological approaches to guarantee their protection, stability, and controlled release. Here, 21 cocoa polyphenol-rich microencapsulates were produced by spray-drying and freeze-drying techniques using two wall materials (maltodextrin and gum arabic). Chemical (total and individual phenolic content and antioxidant activity), structural (morphology), and biological parameters (cytotoxicity, trypanocidal, antioxidant, and immunomodulatory activities) were assessed to determine the most efficient microencapsulation conditions on Trypanosoma cruzi-infected myocardioblast and macrophage cells. Significant antiproliferative properties against infected cells (superior to benznidazole) were found in two microencapsulates which also exhibited cardioprotective properties against oxidative stress, inflammation, and cell death. |
| first_indexed | 2024-03-07T22:01:06Z |
| format | Article |
| id | doaj.art-589429a8f94f479aa82f12bbd74c40e7 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-24T20:14:09Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-589429a8f94f479aa82f12bbd74c40e72024-03-23T06:22:42ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-04-01173116307Microencapsulation of Theobroma cacao L polyphenols: A high-value approach with in vitro anti-Trypanosoma cruzi, immunomodulatory and antioxidant activitiesLaura Vargas-Munévar0Juan Borja-Fajardo1Angélica Sandoval-Aldana2Wendy Quintero García3Erika Moreno Moreno4Juan Camilo Henriquez5Elena Stashenko6Liliana Torcoroma García7Olimpo García-Beltrán8Posgradute Department in Infectious Disease, Universidad de Santander, Bucaramanga 680006, ColombiaFacultad de ingeniería, Universidad del Tolima, Ibagué 730006, ColombiaFacultad de ingeniería, Universidad del Tolima, Ibagué 730006, ColombiaPosgradute Department in Infectious Disease, Universidad de Santander, Bucaramanga 680006, ColombiaPosgradute Department in Infectious Disease, Universidad de Santander, Bucaramanga 680006, ColombiaNational Research Center for the Agroindustrialization of Aromatic and Medicinal Tropical Species (CENIVAM), Universidad Industrial de Santander, Bucaramanga 680002, ColombiaNational Research Center for the Agroindustrialization of Aromatic and Medicinal Tropical Species (CENIVAM), Universidad Industrial de Santander, Bucaramanga 680002, ColombiaPosgradute Department in Infectious Disease, Universidad de Santander, Bucaramanga 680006, Colombia; Corresponding author.Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O′ Higgins, Santiago 8370854, Chile; Facultad de Ciencias Naturales y Matemáticas, Universidad de Ibagué, Ibagué 730002, Colombia; Corresponding author at: Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O′ Higgins, Santiago 8370854, Chile.Chagas disease (CHD) is the highest economic burden parasitosis worldwide and the most important cardiac infection, without therapeutic alternatives to halt or reverse its progression. In CHD-experimental models, antioxidant and anti-inflammatory compounds have demonstrated therapeutic potential in cardiac dysfunction. Theobroma cacao polyphenols are potent natural antioxidants with cardioprotective and anti-inflammatory action, which are susceptible to degradation, requiring technological approaches to guarantee their protection, stability, and controlled release. Here, 21 cocoa polyphenol-rich microencapsulates were produced by spray-drying and freeze-drying techniques using two wall materials (maltodextrin and gum arabic). Chemical (total and individual phenolic content and antioxidant activity), structural (morphology), and biological parameters (cytotoxicity, trypanocidal, antioxidant, and immunomodulatory activities) were assessed to determine the most efficient microencapsulation conditions on Trypanosoma cruzi-infected myocardioblast and macrophage cells. Significant antiproliferative properties against infected cells (superior to benznidazole) were found in two microencapsulates which also exhibited cardioprotective properties against oxidative stress, inflammation, and cell death.http://www.sciencedirect.com/science/article/pii/S0753332224001884Theobroma cacao L.Trypanosoma cruziChagas diseaseAntioxidantPolyphenolsImmunomodulator |
| spellingShingle | Laura Vargas-Munévar Juan Borja-Fajardo Angélica Sandoval-Aldana Wendy Quintero García Erika Moreno Moreno Juan Camilo Henriquez Elena Stashenko Liliana Torcoroma García Olimpo García-Beltrán Microencapsulation of Theobroma cacao L polyphenols: A high-value approach with in vitro anti-Trypanosoma cruzi, immunomodulatory and antioxidant activities Biomedicine & Pharmacotherapy Theobroma cacao L. Trypanosoma cruzi Chagas disease Antioxidant Polyphenols Immunomodulator |
| title | Microencapsulation of Theobroma cacao L polyphenols: A high-value approach with in vitro anti-Trypanosoma cruzi, immunomodulatory and antioxidant activities |
| title_full | Microencapsulation of Theobroma cacao L polyphenols: A high-value approach with in vitro anti-Trypanosoma cruzi, immunomodulatory and antioxidant activities |
| title_fullStr | Microencapsulation of Theobroma cacao L polyphenols: A high-value approach with in vitro anti-Trypanosoma cruzi, immunomodulatory and antioxidant activities |
| title_full_unstemmed | Microencapsulation of Theobroma cacao L polyphenols: A high-value approach with in vitro anti-Trypanosoma cruzi, immunomodulatory and antioxidant activities |
| title_short | Microencapsulation of Theobroma cacao L polyphenols: A high-value approach with in vitro anti-Trypanosoma cruzi, immunomodulatory and antioxidant activities |
| title_sort | microencapsulation of theobroma cacao l polyphenols a high value approach with in vitro anti trypanosoma cruzi immunomodulatory and antioxidant activities |
| topic | Theobroma cacao L. Trypanosoma cruzi Chagas disease Antioxidant Polyphenols Immunomodulator |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224001884 |
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