Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study
Abstract Introduction Effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults need to be further explored. Methods A retrospective, longitudinal, real‐world cohort study was performed. All included cases were divided into vitamin D deficiency (VDD...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-10-01
|
| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.13694 |
| _version_ | 1797668896937869312 |
|---|---|
| author | Denggao Peng Yanzhang Gao Zhichao Liu Jiawei Zheng Yingxia Liu |
| author_facet | Denggao Peng Yanzhang Gao Zhichao Liu Jiawei Zheng Yingxia Liu |
| author_sort | Denggao Peng |
| collection | DOAJ |
| description | Abstract Introduction Effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults need to be further explored. Methods A retrospective, longitudinal, real‐world cohort study was performed. All included cases were divided into vitamin D deficiency (VDD) and non‐VDD (control) groups according to baseline serum 25‐hydroxyvitamin D [25(OH)D] concentration and then into unvaccinated, routinely vaccinated, and booster vaccinated VDD and control subgroups according to vaccination status. Antibody dynamics were observed within six time periods during hospitalization. Results A total of 204 adult cases were included, of which 121 (59%) were males; 23 (11%), 31 (15%), and 26 (13%) or 50 (25%), 35 (17%), and 39 (19%) were unvaccinated, routinely vaccinated, and booster vaccinated VDD cases or controls, respectively. The median (interquartile range) for age and baseline 25(OH)D concentration was 42.5 (31–53.5) years and 21.5 (18–25.4) ng/mL, respectively. The IgM titers within 3 to 7 days and 7 to 14 days increased rapidly to 1.8‐fold (P < 0.001) and 3.6‐fold (P < 0.001) those within the first day; the IgG titers increased to 5.8‐fold (P < 0.001) and 10.9‐fold (P < 0.001). Booster vaccinated controls had higher first IgG titers compared with unvaccinated controls (3.1‐fold; P = 0.001) or booster vaccinated VDD cases (2.1‐fold; P = 0.02). Conclusions Booster vaccination and non‐VDD status may have an interactive boosting effect on IgG production of Omicron variant‐infected adults. Further randomized clinical trials may be needed to determine whether booster vaccination combined with VDD correction improves the humoral immunity to Omicron variants. |
| first_indexed | 2024-03-11T20:36:13Z |
| format | Article |
| id | doaj.art-58952d1bbf1349329596b4e398283c3a |
| institution | Directory Open Access Journal |
| issn | 1752-6981 1752-699X |
| language | English |
| last_indexed | 2024-03-11T20:36:13Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj.art-58952d1bbf1349329596b4e398283c3a2023-10-02T06:33:21ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2023-10-0117101067107610.1111/crj.13694Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort studyDenggao Peng0Yanzhang Gao1Zhichao Liu2Jiawei Zheng3Yingxia Liu4Graduate Collaborative Training Base of Shenzhen Third People's Hospital, Hengyang Medical School University of South China Hengyang ChinaDepartment of Emergency Medicine, Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen ChinaDepartment of Emergency Medicine, Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen ChinaDepartment of Emergency Medicine, Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen ChinaGraduate Collaborative Training Base of Shenzhen Third People's Hospital, Hengyang Medical School University of South China Hengyang ChinaAbstract Introduction Effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults need to be further explored. Methods A retrospective, longitudinal, real‐world cohort study was performed. All included cases were divided into vitamin D deficiency (VDD) and non‐VDD (control) groups according to baseline serum 25‐hydroxyvitamin D [25(OH)D] concentration and then into unvaccinated, routinely vaccinated, and booster vaccinated VDD and control subgroups according to vaccination status. Antibody dynamics were observed within six time periods during hospitalization. Results A total of 204 adult cases were included, of which 121 (59%) were males; 23 (11%), 31 (15%), and 26 (13%) or 50 (25%), 35 (17%), and 39 (19%) were unvaccinated, routinely vaccinated, and booster vaccinated VDD cases or controls, respectively. The median (interquartile range) for age and baseline 25(OH)D concentration was 42.5 (31–53.5) years and 21.5 (18–25.4) ng/mL, respectively. The IgM titers within 3 to 7 days and 7 to 14 days increased rapidly to 1.8‐fold (P < 0.001) and 3.6‐fold (P < 0.001) those within the first day; the IgG titers increased to 5.8‐fold (P < 0.001) and 10.9‐fold (P < 0.001). Booster vaccinated controls had higher first IgG titers compared with unvaccinated controls (3.1‐fold; P = 0.001) or booster vaccinated VDD cases (2.1‐fold; P = 0.02). Conclusions Booster vaccination and non‐VDD status may have an interactive boosting effect on IgG production of Omicron variant‐infected adults. Further randomized clinical trials may be needed to determine whether booster vaccination combined with VDD correction improves the humoral immunity to Omicron variants.https://doi.org/10.1111/crj.13694antibodybooster vaccinationCOVID‐19Omicronvariantvitamin D |
| spellingShingle | Denggao Peng Yanzhang Gao Zhichao Liu Jiawei Zheng Yingxia Liu Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study The Clinical Respiratory Journal antibody booster vaccination COVID‐19 Omicron variant vitamin D |
| title | Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study |
| title_full | Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study |
| title_fullStr | Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study |
| title_full_unstemmed | Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study |
| title_short | Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study |
| title_sort | interactive effect of booster vaccination and vitamin d status on antibody production of omicron variant infected adults a real world cohort study |
| topic | antibody booster vaccination COVID‐19 Omicron variant vitamin D |
| url | https://doi.org/10.1111/crj.13694 |
| work_keys_str_mv | AT denggaopeng interactiveeffectofboostervaccinationandvitamindstatusonantibodyproductionofomicronvariantinfectedadultsarealworldcohortstudy AT yanzhanggao interactiveeffectofboostervaccinationandvitamindstatusonantibodyproductionofomicronvariantinfectedadultsarealworldcohortstudy AT zhichaoliu interactiveeffectofboostervaccinationandvitamindstatusonantibodyproductionofomicronvariantinfectedadultsarealworldcohortstudy AT jiaweizheng interactiveeffectofboostervaccinationandvitamindstatusonantibodyproductionofomicronvariantinfectedadultsarealworldcohortstudy AT yingxialiu interactiveeffectofboostervaccinationandvitamindstatusonantibodyproductionofomicronvariantinfectedadultsarealworldcohortstudy |