Cryo-EM structure of human hexameric MCM2-7 complex

Cryo-EM structure of human hexameric MCM2-7 complex

Summary: The central step in the initiation of eukaryotic DNA replication is the loading of the minichromosome maintenance 2–7 (MCM2-7) complex, the core of the replicative DNA helicase, onto chromatin at replication origin. Here, we reported the cryo-EM structure of endogenous human single hexameri...

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Bibliographic Details
Main Authors: Naining Xu, Qingpeng Lin, Honglei Tian, Changdong Liu, Peiyi Wang, Ching Monica Suen, Hongyu Yang, Ye Xiang, Guang Zhu
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222012482

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