Clinical and genetic aspects of differential diagnostics of hereditary non-polyposis colorectal cancer
Lynch syndrome was synonymous with hereditary non-polyposis colorectal cancer for a long time, however, mapping of the DNA mismatch repair (MMR) genes has led to distinguish Lynch syndrome as an independent syndromic unit from a number of Lynch-like syndromes that phenotypically mimic with the most...
| المؤلفون الرئيسيون: | , , |
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| التنسيق: | مقال |
| اللغة: | Russian |
| منشور في: |
ABV-press
2019-07-01
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| سلاسل: | Успехи молекулярной онкологии |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://umo.abvpress.ru/jour/article/view/215 |
| الملخص: | Lynch syndrome was synonymous with hereditary non-polyposis colorectal cancer for a long time, however, mapping of the DNA mismatch repair (MMR) genes has led to distinguish Lynch syndrome as an independent syndromic unit from a number of Lynch-like syndromes that phenotypically mimic with the most frequent hereditary variant of colon cancer but genetically representing quite a heterogeneous group. This article presents up to date clinical and genetic characteristics of Lynch syndrome and Lynch-like conditions. |
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| تدمد: | 2313-805X 2413-3787 |