A novel and practical asymmetric synthesis of dapoxetine hydrochloride
A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2015-12-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.11.283 |
| _version_ | 1818413038776090624 |
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| author | Yijun Zhu Zhenren Liu Hongyan Li Deyong Ye Weicheng Zhou |
| author_facet | Yijun Zhu Zhenren Liu Hongyan Li Deyong Ye Weicheng Zhou |
| author_sort | Yijun Zhu |
| collection | DOAJ |
| description | A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent. |
| first_indexed | 2024-12-14T10:56:51Z |
| format | Article |
| id | doaj.art-589968f897e34e4aa68d80bee6e2c76f |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-14T10:56:51Z |
| publishDate | 2015-12-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-589968f897e34e4aa68d80bee6e2c76f2022-12-21T23:04:53ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-12-011112641264510.3762/bjoc.11.2831860-5397-11-283A novel and practical asymmetric synthesis of dapoxetine hydrochlorideYijun Zhu0Zhenren Liu1Hongyan Li2Deyong Ye3Weicheng Zhou4State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaState Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaState Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaSchool of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, ChinaState Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaA novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.https://doi.org/10.3762/bjoc.11.283asymmetric synthesisdapoxetine hydrochloridestereoselectivity(S)-tert-butanesulfinamide |
| spellingShingle | Yijun Zhu Zhenren Liu Hongyan Li Deyong Ye Weicheng Zhou A novel and practical asymmetric synthesis of dapoxetine hydrochloride Beilstein Journal of Organic Chemistry asymmetric synthesis dapoxetine hydrochloride stereoselectivity (S)-tert-butanesulfinamide |
| title | A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
| title_full | A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
| title_fullStr | A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
| title_full_unstemmed | A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
| title_short | A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
| title_sort | novel and practical asymmetric synthesis of dapoxetine hydrochloride |
| topic | asymmetric synthesis dapoxetine hydrochloride stereoselectivity (S)-tert-butanesulfinamide |
| url | https://doi.org/10.3762/bjoc.11.283 |
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