Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool
Pancreatic cancer (PC) is an aggressive malignancy with a dismal prognosis. To improve patient survival, the development of screening methods for early diagnosis is pivotal. Oncogenomic alterations present in tumor tissue are a suitable target for non-invasive screening efforts, as they can be detec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/5/652 |
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| author | Heidelinde Sammallahti Virinder Kaur Sarhadi Arto Kokkola Reza Ghanbari Sama Rezasoltani Hamid Asadzadeh Aghdaei Pauli Puolakkainen Sakari Knuutila |
| author_facet | Heidelinde Sammallahti Virinder Kaur Sarhadi Arto Kokkola Reza Ghanbari Sama Rezasoltani Hamid Asadzadeh Aghdaei Pauli Puolakkainen Sakari Knuutila |
| author_sort | Heidelinde Sammallahti |
| collection | DOAJ |
| description | Pancreatic cancer (PC) is an aggressive malignancy with a dismal prognosis. To improve patient survival, the development of screening methods for early diagnosis is pivotal. Oncogenomic alterations present in tumor tissue are a suitable target for non-invasive screening efforts, as they can be detected in tumor-derived cells, cell-free nucleic acids, and extracellular vesicles, which are present in several body fluids. Since stool is an easily accessible source, which enables convenient and cost-effective sampling, it could be utilized for the screening of these traces. Herein, we explore the various oncogenomic changes that have been detected in PC tissue, such as chromosomal aberrations, mutations in driver genes, epigenetic alterations, and differentially expressed non-coding RNA. In addition, we briefly look into the role of altered gut microbiota in PC and their possible associations with oncogenomic changes. We also review the findings of genomic alterations in stool of PC patients, and the potentials and challenges of their future use for the development of stool screening tools, including the possible combination of genomic and microbiota markers. |
| first_indexed | 2024-03-10T03:16:29Z |
| format | Article |
| id | doaj.art-5899769943704ca0ab84dc4a5396ca37 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T03:16:29Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-5899769943704ca0ab84dc4a5396ca372023-11-23T10:13:34ZengMDPI AGBiomolecules2218-273X2022-04-0112565210.3390/biom12050652Oncogenomic Changes in Pancreatic Cancer and Their Detection in StoolHeidelinde Sammallahti0Virinder Kaur Sarhadi1Arto Kokkola2Reza Ghanbari3Sama Rezasoltani4Hamid Asadzadeh Aghdaei5Pauli Puolakkainen6Sakari Knuutila7Department of Pathology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, FinlandDepartment of Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, FinlandDigestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran P.O. Box 1411713135, IranFoodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 1985717411, IranBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 1985717411, IranDepartment of Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, FinlandDepartment of Pathology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, FinlandPancreatic cancer (PC) is an aggressive malignancy with a dismal prognosis. To improve patient survival, the development of screening methods for early diagnosis is pivotal. Oncogenomic alterations present in tumor tissue are a suitable target for non-invasive screening efforts, as they can be detected in tumor-derived cells, cell-free nucleic acids, and extracellular vesicles, which are present in several body fluids. Since stool is an easily accessible source, which enables convenient and cost-effective sampling, it could be utilized for the screening of these traces. Herein, we explore the various oncogenomic changes that have been detected in PC tissue, such as chromosomal aberrations, mutations in driver genes, epigenetic alterations, and differentially expressed non-coding RNA. In addition, we briefly look into the role of altered gut microbiota in PC and their possible associations with oncogenomic changes. We also review the findings of genomic alterations in stool of PC patients, and the potentials and challenges of their future use for the development of stool screening tools, including the possible combination of genomic and microbiota markers.https://www.mdpi.com/2218-273X/12/5/652pancreatic canceroncogenomicsgenomic biomarkersstool screeningnon-invasive screeningearly diagnosis |
| spellingShingle | Heidelinde Sammallahti Virinder Kaur Sarhadi Arto Kokkola Reza Ghanbari Sama Rezasoltani Hamid Asadzadeh Aghdaei Pauli Puolakkainen Sakari Knuutila Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool Biomolecules pancreatic cancer oncogenomics genomic biomarkers stool screening non-invasive screening early diagnosis |
| title | Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool |
| title_full | Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool |
| title_fullStr | Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool |
| title_full_unstemmed | Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool |
| title_short | Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool |
| title_sort | oncogenomic changes in pancreatic cancer and their detection in stool |
| topic | pancreatic cancer oncogenomics genomic biomarkers stool screening non-invasive screening early diagnosis |
| url | https://www.mdpi.com/2218-273X/12/5/652 |
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