Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging
Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as a cancer therapy requires a precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, and their use to enhance ferro...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2024-02-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23002980 |
| _version_ | 1797450912974766080 |
|---|---|
| author | Min Jun Ko Sunhong Min Hyunsik Hong Woojung Yoo Jinmyoung Joo Yu Shrike Zhang Heemin Kang Dong-Hyun Kim |
| author_facet | Min Jun Ko Sunhong Min Hyunsik Hong Woojung Yoo Jinmyoung Joo Yu Shrike Zhang Heemin Kang Dong-Hyun Kim |
| author_sort | Min Jun Ko |
| collection | DOAJ |
| description | Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as a cancer therapy requires a precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, and their use to enhance ferroptosis is indeed a growing area of research. While a few review papers have been published on iron-dependent mechanism and inducers of ferroptosis cancer therapy that partly covers ferroptosis nanoparticles, there is a need for a comprehensive review focusing on the design of magnetic nanoparticles that can typically supply iron ions to promote ferroptosis and simultaneously enable targeted ferroptosis cancer nanomedicine. Furthermore, magnetic nanoparticles can locally induce ferroptosis and combinational ferroptosis with diagnostic magnetic resonance imaging (MRI). The use of remotely controllable magnetic nanocarriers can offer highly effective localized image-guided ferroptosis cancer nanomedicine. Here, recent developments in magnetically manipulable nanocarriers for ferroptosis cancer nanomedicine with medical imaging are summarized. This review also highlights the advantages of current state-of-the-art image-guided ferroptosis cancer nanomedicine. Finally, image guided combinational ferroptosis cancer therapy with conventional apoptosis-based therapy that enables synergistic tumor therapy is discussed for clinical translations. |
| first_indexed | 2024-03-09T14:46:24Z |
| format | Article |
| id | doaj.art-589b87150edc4cb4aa2bc6e4ce3b296c |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-03-09T14:46:24Z |
| publishDate | 2024-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-589b87150edc4cb4aa2bc6e4ce3b296c2023-11-27T04:15:01ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-02-01326697Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imagingMin Jun Ko0Sunhong Min1Hyunsik Hong2Woojung Yoo3Jinmyoung Joo4Yu Shrike Zhang5Heemin Kang6Dong-Hyun Kim7Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USADepartment of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of KoreaDepartment of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of KoreaDepartment of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of KoreaDepartment of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of KoreaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Cambridge, MA, 02139, USADepartment of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea; College of Medicine, Korea University, Seoul, 02841, Republic of Korea; Corresponding author. Department of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea.Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA; Department of Biomedical Engineering, University of Illinois, Chicago, IL, 60607, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, 60611, USA; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, 60208, USA; Corresponding author. Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as a cancer therapy requires a precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, and their use to enhance ferroptosis is indeed a growing area of research. While a few review papers have been published on iron-dependent mechanism and inducers of ferroptosis cancer therapy that partly covers ferroptosis nanoparticles, there is a need for a comprehensive review focusing on the design of magnetic nanoparticles that can typically supply iron ions to promote ferroptosis and simultaneously enable targeted ferroptosis cancer nanomedicine. Furthermore, magnetic nanoparticles can locally induce ferroptosis and combinational ferroptosis with diagnostic magnetic resonance imaging (MRI). The use of remotely controllable magnetic nanocarriers can offer highly effective localized image-guided ferroptosis cancer nanomedicine. Here, recent developments in magnetically manipulable nanocarriers for ferroptosis cancer nanomedicine with medical imaging are summarized. This review also highlights the advantages of current state-of-the-art image-guided ferroptosis cancer nanomedicine. Finally, image guided combinational ferroptosis cancer therapy with conventional apoptosis-based therapy that enables synergistic tumor therapy is discussed for clinical translations.http://www.sciencedirect.com/science/article/pii/S2452199X23002980Magnetic nanoparticlesFerroptosis cancer therapyDiagnostic imagingMagnetic resonance imagingSynergistic cancer imaging and therapy |
| spellingShingle | Min Jun Ko Sunhong Min Hyunsik Hong Woojung Yoo Jinmyoung Joo Yu Shrike Zhang Heemin Kang Dong-Hyun Kim Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging Bioactive Materials Magnetic nanoparticles Ferroptosis cancer therapy Diagnostic imaging Magnetic resonance imaging Synergistic cancer imaging and therapy |
| title | Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging |
| title_full | Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging |
| title_fullStr | Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging |
| title_full_unstemmed | Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging |
| title_short | Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging |
| title_sort | magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging |
| topic | Magnetic nanoparticles Ferroptosis cancer therapy Diagnostic imaging Magnetic resonance imaging Synergistic cancer imaging and therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23002980 |
| work_keys_str_mv | AT minjunko magneticnanoparticlesforferroptosiscancertherapywithdiagnosticimaging AT sunhongmin magneticnanoparticlesforferroptosiscancertherapywithdiagnosticimaging AT hyunsikhong magneticnanoparticlesforferroptosiscancertherapywithdiagnosticimaging AT woojungyoo magneticnanoparticlesforferroptosiscancertherapywithdiagnosticimaging AT jinmyoungjoo magneticnanoparticlesforferroptosiscancertherapywithdiagnosticimaging AT yushrikezhang magneticnanoparticlesforferroptosiscancertherapywithdiagnosticimaging AT heeminkang magneticnanoparticlesforferroptosiscancertherapywithdiagnosticimaging AT donghyunkim magneticnanoparticlesforferroptosiscancertherapywithdiagnosticimaging |