Adverse Intrauterine Environment and Cardiac miRNA Expression
Placental insufficiency, high altitude pregnancies, maternal obesity/diabetes, maternal undernutrition and stress can result in a poor setting for growth of the developing fetus. These adverse intrauterine environments result in physiological changes to the developing heart that impact how the heart...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/18/12/2628 |
| _version_ | 1811313411867279360 |
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| author | Mitchell C. Lock Kimberley J. Botting Ross L. Tellam Doug Brooks Janna L. Morrison |
| author_facet | Mitchell C. Lock Kimberley J. Botting Ross L. Tellam Doug Brooks Janna L. Morrison |
| author_sort | Mitchell C. Lock |
| collection | DOAJ |
| description | Placental insufficiency, high altitude pregnancies, maternal obesity/diabetes, maternal undernutrition and stress can result in a poor setting for growth of the developing fetus. These adverse intrauterine environments result in physiological changes to the developing heart that impact how the heart will function in postnatal life. The intrauterine environment plays a key role in the complex interplay between genes and the epigenetic mechanisms that regulate their expression. In this review we describe how an adverse intrauterine environment can influence the expression of miRNAs (a sub-set of non-coding RNAs) and how these changes may impact heart development. Potential consequences of altered miRNA expression in the fetal heart include; Hypoxia inducible factor (HIF) activation, dysregulation of angiogenesis, mitochondrial abnormalities and altered glucose and fatty acid transport/metabolism. It is important to understand how miRNAs are altered in these adverse environments to identify key pathways that can be targeted using miRNA mimics or inhibitors to condition an improved developmental response. |
| first_indexed | 2024-04-13T10:54:23Z |
| format | Article |
| id | doaj.art-589beb1cb29a47f086ca5e439df7a72c |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T10:54:23Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-589beb1cb29a47f086ca5e439df7a72c2022-12-22T02:49:34ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-12-011812262810.3390/ijms18122628ijms18122628Adverse Intrauterine Environment and Cardiac miRNA ExpressionMitchell C. Lock0Kimberley J. Botting1Ross L. Tellam2Doug Brooks3Janna L. Morrison4Early Origins of Adult Health Research Group; School of Pharmacy & Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, AustraliaEarly Origins of Adult Health Research Group; School of Pharmacy & Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, AustraliaEarly Origins of Adult Health Research Group; School of Pharmacy & Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, AustraliaMechanisms in Cell Biology and Disease Research Group School of Pharmacy & Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, AustraliaEarly Origins of Adult Health Research Group; School of Pharmacy & Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, AustraliaPlacental insufficiency, high altitude pregnancies, maternal obesity/diabetes, maternal undernutrition and stress can result in a poor setting for growth of the developing fetus. These adverse intrauterine environments result in physiological changes to the developing heart that impact how the heart will function in postnatal life. The intrauterine environment plays a key role in the complex interplay between genes and the epigenetic mechanisms that regulate their expression. In this review we describe how an adverse intrauterine environment can influence the expression of miRNAs (a sub-set of non-coding RNAs) and how these changes may impact heart development. Potential consequences of altered miRNA expression in the fetal heart include; Hypoxia inducible factor (HIF) activation, dysregulation of angiogenesis, mitochondrial abnormalities and altered glucose and fatty acid transport/metabolism. It is important to understand how miRNAs are altered in these adverse environments to identify key pathways that can be targeted using miRNA mimics or inhibitors to condition an improved developmental response.https://www.mdpi.com/1422-0067/18/12/2628miRNAepigeneticsheart diseasefetal development |
| spellingShingle | Mitchell C. Lock Kimberley J. Botting Ross L. Tellam Doug Brooks Janna L. Morrison Adverse Intrauterine Environment and Cardiac miRNA Expression International Journal of Molecular Sciences miRNA epigenetics heart disease fetal development |
| title | Adverse Intrauterine Environment and Cardiac miRNA Expression |
| title_full | Adverse Intrauterine Environment and Cardiac miRNA Expression |
| title_fullStr | Adverse Intrauterine Environment and Cardiac miRNA Expression |
| title_full_unstemmed | Adverse Intrauterine Environment and Cardiac miRNA Expression |
| title_short | Adverse Intrauterine Environment and Cardiac miRNA Expression |
| title_sort | adverse intrauterine environment and cardiac mirna expression |
| topic | miRNA epigenetics heart disease fetal development |
| url | https://www.mdpi.com/1422-0067/18/12/2628 |
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