The Role of Surveillance Inspections in Reducing False-Positives of SARS-CoV-2 Omicron Variants during the COVID-19 Epidemic
Objective. This study aims to assess the effectiveness of surveillance inspections conducted by the provincial health committee in Quanzhou city during a COVID-19 outbreak in reducing false-positive results in SARS-CoV-2 RT-PCR assays. Method. The team conducted on-site inspections of laboratories t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2023/8508975 |
| _version_ | 1797838702170341376 |
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| author | Li-Li Liu Yu-Hong Zheng You-Quan Zhang Jin-Piao Lin Zhi-Lin Luo Liu-Min Yu Shi-Hua Gao Falin Chen |
| author_facet | Li-Li Liu Yu-Hong Zheng You-Quan Zhang Jin-Piao Lin Zhi-Lin Luo Liu-Min Yu Shi-Hua Gao Falin Chen |
| author_sort | Li-Li Liu |
| collection | DOAJ |
| description | Objective. This study aims to assess the effectiveness of surveillance inspections conducted by the provincial health committee in Quanzhou city during a COVID-19 outbreak in reducing false-positive results in SARS-CoV-2 RT-PCR assays. Method. The team conducted on-site inspections of laboratories that participated in mass screening, recording any violations of rules. Results. The positive cases in five rounds of mass screening were 23, 173, and 4 in Licheng District, Fengze District, and Luojang District, respectively. The false-positive rates in the five rounds of mass screening were 0.0099%, 0.0063%, 0.0018%, 0.0006%, and 0%, respectively. The study also recorded that the number of violations in the seven selected laboratories was 36, 68, 69, 42, 60, 54 and 47. The corresponding false-positive rates were 0.0012%, 0.0060%, 0.0082%, 0.0032%, 0.0060%, 0.0027%, and 0.0021%, respectively. The study found a positive correlation between false-positive rates and the number of violations (r = 0.905, P=0.005), and an inverse correlation between false-positive rates and the frequency of surveillance inspections (r = −0.950, P<0.001). Conclusion. Daily surveillance inspection in laboratories can remind laboratories to strictly comply with standard procedures, focus on laboratory quality control, and reduce the occurrence of false-positive cases in SARS-CoV-2 nucleic acid tests to some extent. This study recommends that government decision-making departments establish policies and arrange experts to conduct daily surveillance inspections to improve laboratory quality control. |
| first_indexed | 2024-04-09T15:46:12Z |
| format | Article |
| id | doaj.art-589c011454b447198d2e59d905cff805 |
| institution | Directory Open Access Journal |
| issn | 1918-1493 |
| language | English |
| last_indexed | 2024-04-09T15:46:12Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj.art-589c011454b447198d2e59d905cff8052023-04-27T00:00:03ZengHindawi LimitedCanadian Journal of Infectious Diseases and Medical Microbiology1918-14932023-01-01202310.1155/2023/8508975The Role of Surveillance Inspections in Reducing False-Positives of SARS-CoV-2 Omicron Variants during the COVID-19 EpidemicLi-Li Liu0Yu-Hong Zheng1You-Quan Zhang2Jin-Piao Lin3Zhi-Lin Luo4Liu-Min Yu5Shi-Hua Gao6Falin Chen7Department of Center of Clinical LaboratoryDepartment of LaboratoryDepartment of LaboratoryDepartment of LaboratoryDepartment of LaboratoryDepartment of LaboratoryThe Affiliated Hospital of Fujian Medical University of First Hospital of NanpingDepartment of Clinical LaboratoryObjective. This study aims to assess the effectiveness of surveillance inspections conducted by the provincial health committee in Quanzhou city during a COVID-19 outbreak in reducing false-positive results in SARS-CoV-2 RT-PCR assays. Method. The team conducted on-site inspections of laboratories that participated in mass screening, recording any violations of rules. Results. The positive cases in five rounds of mass screening were 23, 173, and 4 in Licheng District, Fengze District, and Luojang District, respectively. The false-positive rates in the five rounds of mass screening were 0.0099%, 0.0063%, 0.0018%, 0.0006%, and 0%, respectively. The study also recorded that the number of violations in the seven selected laboratories was 36, 68, 69, 42, 60, 54 and 47. The corresponding false-positive rates were 0.0012%, 0.0060%, 0.0082%, 0.0032%, 0.0060%, 0.0027%, and 0.0021%, respectively. The study found a positive correlation between false-positive rates and the number of violations (r = 0.905, P=0.005), and an inverse correlation between false-positive rates and the frequency of surveillance inspections (r = −0.950, P<0.001). Conclusion. Daily surveillance inspection in laboratories can remind laboratories to strictly comply with standard procedures, focus on laboratory quality control, and reduce the occurrence of false-positive cases in SARS-CoV-2 nucleic acid tests to some extent. This study recommends that government decision-making departments establish policies and arrange experts to conduct daily surveillance inspections to improve laboratory quality control.http://dx.doi.org/10.1155/2023/8508975 |
| spellingShingle | Li-Li Liu Yu-Hong Zheng You-Quan Zhang Jin-Piao Lin Zhi-Lin Luo Liu-Min Yu Shi-Hua Gao Falin Chen The Role of Surveillance Inspections in Reducing False-Positives of SARS-CoV-2 Omicron Variants during the COVID-19 Epidemic Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | The Role of Surveillance Inspections in Reducing False-Positives of SARS-CoV-2 Omicron Variants during the COVID-19 Epidemic |
| title_full | The Role of Surveillance Inspections in Reducing False-Positives of SARS-CoV-2 Omicron Variants during the COVID-19 Epidemic |
| title_fullStr | The Role of Surveillance Inspections in Reducing False-Positives of SARS-CoV-2 Omicron Variants during the COVID-19 Epidemic |
| title_full_unstemmed | The Role of Surveillance Inspections in Reducing False-Positives of SARS-CoV-2 Omicron Variants during the COVID-19 Epidemic |
| title_short | The Role of Surveillance Inspections in Reducing False-Positives of SARS-CoV-2 Omicron Variants during the COVID-19 Epidemic |
| title_sort | role of surveillance inspections in reducing false positives of sars cov 2 omicron variants during the covid 19 epidemic |
| url | http://dx.doi.org/10.1155/2023/8508975 |
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